Université de Toulouse
2 weeks ago
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PhD in 3D Bio-Based mRNA-Enriched Materials for Bone Regeneration and AI-Based Osteogenic Optimization CEA University of Toulouse DOCC in France
Degree Level
PhD
Field of study
Computer Science
Funding
Public/private funding. This is a funded PhD thesis position; no stipend amount, tuition coverage, or additional financial details are specified.
Deadline
Sep 4, 2026
Country
France
University
Université de Toulouse

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About this position
PhD opportunity in France on 3D bio-based mRNA-enriched materials for bone regeneration and AI-based optimization of osteogenic differentiation.
The project develops bioresorbable scaffolds functionalized with mRNA using poly(L-lysine) and hyaluronic acid, with different 3D architectures. The research combines biomaterials, polymer science, biotechnology, nanobiology, and artificial intelligence to optimize scaffold composition, architecture, and mRNA loading.
The biological goal is to deliver mRNA encoding key bone-regeneration proteins such as VEGF and BMP, transforming cells at the lesion site into local therapeutic protein producers through in situ transfection. The project aims to improve osteogenic differentiation while reducing experimental iterations through AI-assisted design and data analysis.
The position is hosted at CEA University of Toulouse DOCC with workplace in Grenoble, in collaboration with CIRIMAT UMR 5085 CNRS UT INP. The doctoral school is Material Sciences (ED482), and the thesis director is Sophie Girod Fullana.
Funding: Public/private funding.
Eligibility: Master's degree or engineering degree (or equivalent) in materials chemistry, polymer science, pharmaceutical sciences, or biotechnology.
Deadline: 2026-09-04. Desired start date: 2026-10-01.
Funding details
Public/private funding. This is a funded PhD thesis position; no stipend amount, tuition coverage, or additional financial details are specified.
What's required
Master's degree or engineering degree (or equivalent) in materials chemistry, polymer science, pharmaceutical sciences, or biotechnology. The candidate should be prepared for interdisciplinary research involving biomaterials, mRNA-functionalized scaffolds, osteogenic differentiation, AI-assisted data analysis, scientific writing, and conference dissemination.
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