Publisher
source

Vrije Universiteit Brussel

PhD in Nanobody Development for GPRC5B at Vrije Universiteit Brussel Vrije Universiteit Brussel in Belgium

Degree Level

PhD

Field of study

Chemistry

Funding

MSCA-DN PhD position; doctoral grant/employment through Vrije Universiteit Brussel. The post indicates a funded PhD position within the POLARIS consortium, but no stipend amount or tuition details are given.

Deadline

Oct 5, 2026

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Country

Belgium

University

Vrije Universiteit Brussel

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Keywords

Chemistry
Biomedical Engineering
Biology
Medical Science
Psychotherapy
Molecular Imaging
Signaling Biology

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About this position

PhD opportunity in nanobody development for GPRC5B at Vrije Universiteit Brussel (VUB)

This MSCA-DN doctoral position is hosted by the Molecular Imaging and Therapy (MITH) research group at Vrije Universiteit Brussel and embedded in the POLARIS consortium. The project focuses on developing GPRC5B-targeting nanobodies for use as research tools, diagnostic tracers, and/or therapeutics.

The successful candidate will work on selecting nanobodies from immune and synthetic nanobody libraries, evaluating AI-generated candidates, and characterising the resulting binders in in vitro and in vivo systems. Research topics include affinity, specificity, stability, modulatory effects, biodistribution, and functional effects on GPRC5B signalling.

The position includes planned secondments, offering hands-on experience in the generation and validation of AI-generated GPRC5B-targeting nanobodies at DPTX and functional characterisation at Vrije Universiteit Amsterdam. Academic supervision is provided by Prof. Timo De Groof and Prof. Nick Devoogdt.

This is a PhD opening with a doctoral grant under the MSCA Doctoral Network framework. No stipend amount, tuition coverage, or additional funding details are stated in the post.

Deadline: 5 October 2026.

How to apply: Use the AcademicTransfer application page linked in the post and submit your application before the deadline.

Funding details

MSCA-DN PhD position; doctoral grant/employment through Vrije Universiteit Brussel. The post indicates a funded PhD position within the POLARIS consortium, but no stipend amount or tuition details are given.

What's required

PhD-level doctoral project in nanobody development; candidates should be able to work on selecting nanobodies from immune and synthetic libraries, evaluating AI-generated candidates, and performing in vitro and in vivo characterisation. The post implies interest in affinity, specificity, stability, biodistribution, and functional signalling studies, with collaboration across consortium partners and secondments.

How to apply

Apply via the AcademicTransfer link provided in the post. Review the full vacancy details and submit the application through the portal before the deadline.

More information can be found here

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