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University of Amsterdam

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PhD in Neuroscience: Vascular Clearance, Brain Networks, Aging, and Alzheimer’s Disease University of Amsterdam in Netherlands

Degree Level

PhD

Field of study

Epileptology

Funding

Paid PhD employment at the University of Amsterdam for 38 hours per week for 4 years. Salary ranges from €3,204 gross per month in the first year to €4,051 gross per month in the last year, excluding 8% holiday pay and 8.3% year-end bonus. A 30% ruling may apply to non-Dutch applicants.

Deadline

Oct 15, 2026

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Country

Netherlands

University

University of Amsterdam

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Keywords

Epileptology
Biology
Optogenetics
Aging
Alzheimer's Disease
Neuropsychology
Medical Science

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About this position

PhD candidate opportunity at the University of Amsterdam (Faculty of Science, Swammerdam Institute for Life Sciences) in neuroscience, with a strong focus on aging biology, Alzheimer’s disease, brain networks, and neurovascular dysfunction.

The project asks how loss of vascular clearance mechanisms, especially endothelial LRP1, disrupts brain-wide circuits involving the thalamus, cortex, hippocampus, and cerebellum. You will test whether impaired vascular clearance leads to altered coherence, increased excitability, disturbed sleep, and worsened amyloid pathology, and whether interventions such as PDE1 inhibition and deep brain stimulation can restore vascular and neural circuit function.

Training and methods include patch-clamp electrophysiology, optogenetics, mouse behavior, stereotaxic surgery, histology, and data analysis. The role also includes assisting in teaching and supervising BSc/MSc interns, participating in PhD/Graduate School Neurosciences training, and presenting at national and international meetings.

Eligibility highlights: a recent MSc in neuroscience or a related field, strong motivation for fundamental research, willingness to work with mice, fluent English, and Art. 9 qualification or willingness to obtain it. Experience with mouse handling, histology, whole-cell patch-clamp, or in vivo electrophysiology is an advantage.

This is a paid PhD position for 4 years, with a salary from €3,204 to €4,051 gross per month plus holiday allowance and year-end bonus. The preferred start date is 1 January 2027. Applications close on 15 October 2026.

Funding details

Paid PhD employment at the University of Amsterdam for 38 hours per week for 4 years. Salary ranges from €3,204 gross per month in the first year to €4,051 gross per month in the last year, excluding 8% holiday pay and 8.3% year-end bonus. A 30% ruling may apply to non-Dutch applicants.

What's required

Recent MSc degree in neuroscience or a related area; strong interest in aging biology and Alzheimer’s disease; strong intrinsic motivation and aptitude for fundamental research; willingness to work with mice; willingness to supervise BSc and/or MSc students during internships; fluent English, written and spoken; Art. 9 qualification or willingness to obtain it. Hands-on experience with mouse handling, histology, whole-cell patch-clamp, or in vivo electrophysiology is advantageous.

How to apply

Apply online via the vacancy page before 15 October 2026. Submit a CV with months listed for education and work experience, a motivation letter, and the names and email addresses of two references in one single PDF file besides your CV. Contact Gil Vantomme or Erwin van Vliet for questions.

More information can be found here

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