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Karolinska Institutet

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PhD in Rheumatology: Molecular Signatures in Rheumatic Diseases and JAK Inhibitor Effects Karolinska Institutet in Sweden

Degree Level

PhD

Field of study

Computer Science

Funding

Doctoral student employment for up to 4 years full-time, with salary according to Karolinska Institutet's doctoral salary scale. The post is an employed PhD position rather than a scholarship.

Deadline

Oct 1, 2026

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Country

Sweden

University

Karolinska Institutet

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Keywords

Computer Science
Chemistry
Rheumatology
Biology
Translational Medicine
Medical Science
Salud Pública
Lc-ms
Inflammatory Disease
Statistics
Bioinformatic
Lipidomic
Metabolomic

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About this position

Karolinska Institutet is advertising a doctoral student position in rheumatology within the research group Translational medical research in inflammatory diseases, led by Professor Per-Johan Jakobsson at the Department of Rheumatology, Center for Molecular Medicine.

The project focuses on molecular signatures in rheumatic diseases and treatment response, with emphasis on systemic lupus erythematosus (SLE), axial spondyloarthritis (axSpA), and rheumatoid arthritis (RA). Methods include metabolomics, lipidomics, autoantibody profiling, targeted molecular analyses, whole blood assays, LC-MS-based analyses, statistical analysis, bioinformatics, and integration of molecular and clinical data. A specific part of the project examines the molecular effects of JAK inhibitors and their relevance for cardiovascular safety.

The doctoral student will help plan and perform experiments, analyze and interpret data, validate biomarkers, document results, and contribute to scientific publications and the doctoral thesis. The environment is described as international, creative, and collaborative, with access to courses, supervision, and opportunities for international exchange.

Eligibility: applicants must meet the general doctoral education requirement (master’s degree or equivalent, or 240 higher education credits including 60 advanced-level credits) and the specific English requirement (English B/English 6 or equivalent). The post also requires experience with laboratory work in sterile conditions and LC-MS-based analysis; cell culture and BSL-2 experience are advantageous. Training in biomedicine, analytical chemistry, or molecular biology is desirable, and experience with Bruker QTOF or Waters TQXS, statistics, programming, bioinformatics, and scientific communication is a plus.

Funding: this is an employed PhD position for up to 4 years full-time, with salary according to Karolinska Institutet’s doctoral salary scale.

Location: Solna, Sweden.

Application: apply in the Varbi recruitment system. Include a cover letter, CV, theses/publications, and documents proving eligibility and relevant skills. Deadline: 2026-10-01.

Funding details

Doctoral student employment for up to 4 years full-time, with salary according to Karolinska Institutet's doctoral salary scale. The post is an employed PhD position rather than a scholarship.

What's required

Applicants must have a second-cycle degree (master's level) or equivalent, or at least 240 higher education credits including at least 60 credits at advanced level, and must demonstrate English proficiency equivalent to English B/English 6. The post seeks a motivated, careful, and curious candidate with an interest in translational research on inflammatory and rheumatic diseases, strong analytical and problem-solving ability, and the capacity to independently plan and carry out experiments and analyze results. Required experience includes laboratory work in sterile conditions and LC-MS-based analysis; cell culture and BSL-2 experience are meritorious. Education in biomedicine, analytical chemistry, molecular biology, or equivalent is desirable. Experience with Bruker QTOF or Waters TQXS, statistics, programming, bioinformatics, scientific communication, and teamwork are advantageous.

How to apply

Apply through the Varbi recruitment system using the button on the job page. Submit a cover letter, CV, any theses and publications, supporting documents for the eligibility requirements, and other documents showing relevant skills and experience. Applications may be written in English or Swedish.

More information can be found here

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