Publisher
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University of Dundee

PhD in Targeting Proteasome Assembly to Uncover Cancer Vulnerabilities University of Dundee in United Kingdom

Degree Level

PhD

Field of study

Cell Biology

Funding

4-year PhD studentship funded by the EastBio BBSRC Doctoral Landscape Award. Provides a stipend at the UKRI standard rate and UK-level tuition fees; the University of Dundee covers the Home-International fee difference. Includes a mandatory 3-month placement and training programme.

Deadline

Nov 16, 2026

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Country

United Kingdom

University

University of Dundee

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Keywords

Cell Biology
Biochemistry
Cancer Biology
Biology
High-throughput Screening
Medical Science
Cell Culture Techniques
Protein Degradation

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About this position

PhD opportunity at the University of Dundee in cancer biology, proteasome assembly, protein degradation, and drug discovery.

This EASTBIO-funded project, hosted in the Rousseau laboratory at the University of Dundee and involving the Dundee Drug Discovery Unit, asks whether blocking proteasome assembly can reveal new vulnerabilities in cancer cells. The project uses a newly developed 26S-splitNanoLuc reporter to monitor proteasome assembly in living cells and identify small molecules that interfere with proteasome formation or stability.

You will screen candidate compounds, validate hits with biochemical and cellular assays, and study how these compounds affect protein degradation, cellular stress, and cancer cell survival. The work also explores how cells adapt to reduced proteasome function and whether disrupting those adaptations increases sensitivity to proteasome assembly inhibitors.

Training includes quantitative luminescence assays, high-throughput screening, human cell culture, CRISPR/Cas9 genome engineering, protein biochemistry, and advanced microscopy. The project is suitable for students interested in the interface of fundamental biology and translational drug discovery.

Funding: 4-year PhD studentship funded by the EastBio BBSRC Doctoral Landscape Award. It provides a stipend at the UKRI standard rate and covers UK tuition fees; the University of Dundee covers the Home-International fee difference. A mandatory 3-month placement is included.

Eligibility: Open to UK and international students.

How to apply: Visit the University of Dundee programme page for full application details and instructions.

Funding details

4-year PhD studentship funded by the EastBio BBSRC Doctoral Landscape Award. Provides a stipend at the UKRI standard rate and UK-level tuition fees; the University of Dundee covers the Home-International fee difference. Includes a mandatory 3-month placement and training programme.

What's required

Applicants should be talented individuals interested in postgraduate research in biological sciences. The project is open to UK and international students. Training will involve quantitative luminescence assays, high-throughput screening, human cell culture, CRISPR/Cas9 genome engineering, protein biochemistry and advanced microscopy; strong interest in cancer biology, molecular biology and drug discovery is relevant.

How to apply

See the University of Dundee programme page for further information and application instructions. Apply via the programme page linked in the post.

More information can be found here

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