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International PhD Programme (IPP) Mainz, Institute of Molecular Biology

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PhD Position: Maintaining Proteostasis in Aging (m/f/d) International PhD Programme Mainz, Institute of Molecular Biology in Germany

Degree Level

PhD

Field of study

Cell Biology

Funding

Available

Deadline

Oct 15, 2026

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Country

Germany

University

International PhD Programme (IPP) Mainz, Institute of Molecular Biology

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Keywords

Cell Biology
Molecular Biology
Biology
Microscopy
Aging
Autophagy
Neuropsychology
Medical Science
Proteostasis
Neurodegenerative Disease
Protein Folding
Transcriptomic

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About this position

The International PhD Programme (IPP) Mainz at the Institute of Molecular Biology in Germany is offering a fully funded PhD position in the life sciences on Maintaining Proteostasis in Aging. The project is hosted by the research groups of Anton Khmelinskii and Jan Padeken and focuses on how small-molecule modulators of proteostasis may help preserve cellular function during aging and potentially counteract protein misfolding diseases.

The PhD project investigates the therapeutic applications of small molecule osmolytes such as betaine and taurine. These compounds are thought to mitigate proteotoxic stress, and the project aims to understand how they act in human cellular model systems and in C. elegans as a model of organismal aging. Research questions include how osmolytes affect cellular and organismal physiology, which stresses can be mitigated by exogenous osmolytes, and whether they can ameliorate protein misfolding pathologies linked to neurodegenerative diseases including ALS, frontotemporal dementia, Alzheimer's disease, Parkinson's disease, and Huntington's disease.

The project offers training in transcriptomics, proteomics, cell and molecular biology, fluorescence microscopy, and advanced high-throughput mutagenesis screening. It is part of a collaboration between the Khmelinskii and Padeken groups, giving the successful applicant the chance to work in a highly interdisciplinary and international environment with access to state-of-the-art core facilities at IMB Mainz.

Eligibility requirements are a master’s degree or equivalent, good English skills, an interactive personality, and two letters of reference. The position is advertised as fully funded, with financing available until completion of the thesis. Applications must be submitted through the IPP online application platform, and applicants should select the Khmelinskii/Padeken group preference. The deadline is 15 October 2026, interviews are planned for 18–19 January 2027, and the starting date is expected between 1 February and 31 July 2027.

Funding details

Available

What's required

Master degree or equivalent in a relevant field; good command of English; interactive personality; 2 letters of reference.

How to apply

Apply via the online form using the application button at https://www.imb.de/phd/apply. In the IPP application platform, select Khmelinskii/Padeken as your group preference. Submit before 15 October 2026.

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