The University of Texas MD Anderson Cancer Center
4 days ago
Postdoctoral Fellow in Molecular Oncology and Melanoma Immunotherapy Resistance The University of Texas MD Anderson Cancer Center in United States
Degree Level
Postdoc
Field of study
Oncology
Funding
Full-time postdoctoral position with salary ranging from $64,000 to $76,000 depending on years of postgraduate experience. Benefits include medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and recognition programs.
Country
United States
University
The University of Texas MD Anderson Cancer Center
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About this position
MD Anderson Cancer Center is advertising a Postdoctoral Fellow position in Molecular Oncology in Houston, Texas, United States.
The project focuses on a newly defined metabolic-immune circuit that drives resistance to immune checkpoint inhibitors in melanoma. The fellow will study the pathway linking ICI-induced inflammation, hepatic PAH degradation, systemic phenylalanine accumulation, neutrophil GRIK1-CaMKIV-STING signaling, and CD8+ T cell exhaustion. The work includes testing clinically compatible interventions such as hepatocyte-targeted HULC RNA mimetics and repurposed topiramate.
Research methods and systems include genetically engineered and humanized mouse models, patient-derived melanoma models, hiPSC-derived hepatocytes, RNA therapeutic delivery, multiplex spatial proteomics, bulk RNA-seq, scRNA-seq, flow cytometry, phospho-flow, CyTOF, ELISA, Seahorse assays, CRISPR/Cas9 editing, immunoblotting, and in vitro kinase assays.
Eligibility requires a PhD, MD, or MD/PhD (or expected within six months) in immunology, cancer biology, molecular biology, biochemistry, pharmacology, or a related field. Applicants should have at least one first-author publication and hands-on experience with in vivo tumor studies, mouse colony management, genotyping, IACUC compliance, multicolor flow cytometry, and core molecular/biochemical techniques. Strong English communication and the ability to work independently in a multidisciplinary team are also required.
The position is full-time and offers a salary of $64,000 to $76,000 depending on postgraduate experience, plus benefits including medical, dental, paid time off, retirement, tuition benefits, and educational opportunities.
To apply, use the job posting’s APPLY button and submit materials through the online portal. No deadline is listed in the posting.
Funding details
Full-time postdoctoral position with salary ranging from $64,000 to $76,000 depending on years of postgraduate experience. Benefits include medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and recognition programs.
What's required
PhD, MD, or MD/PhD, or expected within six months, in immunology, cancer biology, molecular biology, biochemistry, pharmacology, or a related discipline. Applicants should have at least one first-author publication in a peer-reviewed journal. Required experience includes in vivo tumor studies, mouse colony management, genotyping, IACUC compliance, multicolor flow cytometry, tissue dissociation, analysis of tumor-infiltrating immune populations, immunoblotting, co-immunoprecipitation, qRT-PCR, ELISA, plasmid and lentiviral construct generation, CRISPR/Cas9 editing, primary cell culture, and strong written and spoken English. Quantitative rigor, statistical testing, power considerations, blinding, randomization, and transparent record keeping are expected.
How to apply
Apply through the MD Anderson job posting using the APPLY button on the job page. Review the eligibility requirements and submit your application materials via the online portal.
More information can be found here
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