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Karolinska Institutet

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Postdoctoral Fellow in mRNA-based CAR T-cell Therapy and Human Immunology Karolinska Institutet in Sweden

Degree Level

Postdoc

Field of study

Immunotherapy

Funding

Fixed-term full-time postdoctoral employment at Karolinska Institutet. Salary is set individually according to collective agreements (RALS and RALS-T). No stipend amount is stated.

Deadline

Oct 6, 2026

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Country

Sweden

University

Karolinska Institutet

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Keywords

Immunotherapy
Biomedical Engineering
Biology
Medical Science
Cell Therapy
T Cell Biology
Omics
Chronic Lymphocytic Leukemia
Lipid Nanoparticles

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About this position

Karolinska Institutet is advertising a postdoctoral fellow position in mRNA-based CAR T-cell therapy within the research environment of Marcus Buggert’s group at the Center for Infectious Medicine (CIM), Department of Medicine, Huddinge. The project sits at the intersection of human immunology, T-cell biology, and cancer immunotherapy, with a focus on chronic lymphocytic leukemia (CLL) and the development of CD19-targeted CAR T cells using mRNA and targeted lipid nanoparticles (tLNPs).

The successful candidate will work on experimental strategies to generate CAR T cells by electroporation and tLNP delivery, culture primary human cells, and run functional co-culture assays to study CAR expression, killing kinetics, and repeated target-cell elimination. The project also includes high-parameter flow cytometry, live-cell imaging, phenotypic and transcriptional/epigenetic analyses, and mechanistic studies of T-cell dysfunction, differentiation, and cytotoxicity in the context of CLL.

This is a research-intensive postdoctoral role requiring independent planning and execution of experiments, data analysis, and contribution to scientific publications. The post emphasizes experience with experimental human immunology, flow cytometry, functional cell-based assays, and ideally prior work with CAR T cells, RNA-based cell modification, primary patient samples, hematological malignancies, single-cell RNA-seq, ATAC-seq, or bioinformatics.

Eligibility: applicants must hold a doctoral degree or equivalent by the time the employment decision is made. A PhD in immunology, biomedicine, cell biology, molecular biology, or a related field is required. Very good English communication skills are required.

Employment details: fixed-term, full-time position at Karolinska Institutet. The workplace location is Flemingsberg, Sweden. Salary is individually set according to collective agreements; no stipend amount is listed.

How to apply: submit the application via the Varbi recruitment system. Required documents include proof of doctoral degree, a complete CV with dissertation date and academic details, a full publication list, and a one-page summary of current work. The deadline is 2026-10-06.

Funding details

Fixed-term full-time postdoctoral employment at Karolinska Institutet. Salary is set individually according to collective agreements (RALS and RALS-T). No stipend amount is stated.

What's required

Applicants must have a doctoral degree or equivalent foreign degree by the time of the employment decision. A PhD in immunology, biomedicine, cell biology, molecular biology, or a related field is required. Strong documented experience in experimental human immunology, T-cell biology, flow cytometry, and functional cell-based assays is expected. Experience with CAR T cells, RNA-based cell modification, hematological malignancies, primary patient samples, cell sorting, cytotoxicity assays, co-culture systems, live-cell imaging, molecular biology, CAR design, single-cell RNA-seq, ATAC-seq, or bioinformatic analysis is advantageous. Very good spoken and written English is required.

How to apply

Apply through the Varbi recruitment system. Prepare proof of doctoral degree, a complete CV including dissertation date and academic details, a full publication list, and a one-page summary of current work in English or Swedish.

More information can be found here

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