The Halin Lab at ETH Zürich is seeking a postdoctoral researcher for a project focused on 3D imaging and organ-on-chip models of human lung lymphatics. This research sits at the intersection of immunology, lymphatic vascular biology, and advanced microscopy, aiming to unravel the structure and function of pulmonary lymphatic networks in both healthy and chronic lung disease states, particularly chronic obstructive pulmonary disease (COPD).

Funded by the Swiss National Science Foundation (SNSF) and conducted in collaboration with the University of Bern, the project leverages cutting-edge 3D microscopy, organ-on-chip technology, and mechanobiological approaches to study lymphatic remodeling and immune cell dynamics. The successful candidate will collaborate with partners in Bern to develop multi-compartment organ-on-chip systems that integrate lymphatic and vascular networks under physiologically relevant mechanical conditions. Key responsibilities include characterizing these networks in terms of morphology and function, studying lymphangiogenesis, immune cell recruitment, and lymphatic drainage under both steady-state and COPD-like inflammatory conditions, and investigating 3D lymphatic and blood vascular networks in human lung tissues using light-sheet and confocal microscopy.

The position offers a stimulating and supportive international research environment within the Institute of Pharmaceutical Sciences at ETH Zürich, access to state-of-the-art facilities and technologies, and close collaboration with multidisciplinary teams and clinician scientists at the University of Bern. The successful candidate will also contribute to the teaching and supervision of Master’s students at ETH Zürich.

Applicants should have a PhD in Vascular Biology, Cell Biology, Mechanobiology, or a related field, with solid expertise in vascular biology, ideally complemented by knowledge of mechanobiology and microfluidic engineering. Excellent microscopy skills (confocal, multiphoton, and ideally light-sheet imaging), hands-on experience with primary endothelial cell culture and standard molecular techniques (flow cytometry, Western blot, qPCR, ELISA), and experience with organ-on-chip or microphysiological systems are highly desirable. First-author publication(s) in peer-reviewed journals, excellent oral and written communication skills in English, and the ability to work independently and collaboratively within a multidisciplinary team are required.

The position is funded for four years, with a competitive salary and employment conditions in accordance with ETH Zürich and SNSF regulations. ETH Zürich values diversity and sustainability, promoting an inclusive culture and equal opportunities for all staff and students. The position will remain open until filled.

To apply, submit your application online via the ETH Zürich application portal, including your CV, publication list, motivation letter, university degree certificates, and names and contact details of two referees. Applications via email or postal services will not be considered. For scientific inquiries, contact Prof. Dr. Cornelia Halin Winter at [email protected].