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St. Jude Children's Research Hospital

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Postdoctoral Research Associate in Quantitative Microscopy, Live-Cell Chromatin Imaging, and Developmental Neuroscience St. Jude Children's Research Hospital in United States

Degree Level

Postdoc

Field of study

Computer Science

Funding

Full-time postdoctoral research associate position at St. Jude Children's Research Hospital; funding/stipend details are not specified in the post.

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Country

United States

University

St. Jude Children's Research Hospital

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Keywords

Computer Science
Chemistry
Biomedical Engineering
Biology
Neuropsychology
Super-resolution Microscopy
Chromatin Biology
Developmental Neuroscience
Physics

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About this position

St. Jude Children's Research Hospital is recruiting a Postdoctoral Research Associate in the Solecki Lab for work at the interface of quantitative microscopy, live-cell chromatin imaging, chromatin biology, and developmental neuroscience.

The project focuses on building imaging-based biosensor platforms that make chromatin states directly visible and measurable in living neurons. Fellows will develop and apply advanced microscopy approaches to study chromatin-state transitions, nuclear organization, epigenetic regulation, and neuronal differentiation as neurons mature and assemble into brain circuits.

Research may involve live-cell imaging, lattice light-sheet microscopy, super-resolution microscopy, neuronal differentiation systems, acute perturbations, fluorescent probes, biosensors, HaloTag/SNAP-tag systems, protein engineering, and computational image analysis. The lab emphasizes creating new experimental frameworks, not just using existing tools, and the successful candidate will help develop probes, assays, imaging strategies, perturbation workflows, and quantitative analysis pipelines.

Applicants should hold a PhD in cell biology, biophysics, gene regulation, neuroscience, or a related field. Strong experience in live-cell imaging or advanced microscopy is preferred, along with quantitative image analysis skills (Python, MATLAB, R, Fiji/ImageJ, Imaris, or similar). A strong publication record is expected; experience with segmentation, tracking, registration, time-series analysis, or automated image processing is a plus.

The position is full-time and based in Memphis, Tennessee, USA. To apply, send a CV, research interests, career aspirations, and contact details for three referees to David J. Solecki at St. Jude Children's Research Hospital.

Funding details

Full-time postdoctoral research associate position at St. Jude Children's Research Hospital; funding/stipend details are not specified in the post.

What's required

A PhD in cell biology, biophysics, gene regulation, neuroscience, or a related discipline is required. Prior experience with live-cell imaging, advanced microscopy, super-resolution microscopy, single-molecule imaging, lattice light-sheet microscopy, or imaging probe development is preferred. Applicants should be interested in chromatin organization, nuclear dynamics, epigenetic regulation, or neuronal differentiation, and have familiarity with quantitative image analysis tools such as Python, MATLAB, R, Fiji/ImageJ, or Imaris. A strong record of peer-reviewed publications is expected. Experience with segmentation, tracking, registration, time-series analysis, automated image-processing workflows, fluorescent probes, biosensors, HaloTag/SNAP-tag systems, protein engineering, or live-cell assay development is desirable.

How to apply

Prepare a CV, a description of research interests, an outline of career aspirations, and contact information for 3 referees. Send the application materials to David J. Solecki at [email protected].

More information can be found here

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