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Anniina Vihervaara

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Assistant Professor at KTH Royal Institute of Technology

KTH Royal Institute of Technology
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Sweden

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About

Anniina Vihervaara is an Assistant Professor at KTH Royal Institute of Technology in Sweden. Her research primarily focuses on transcriptional regulation, RNA synthesis, and molecular modifications of RNA polymerase II complexes, as evidenced by her recent publications. She is involved in exploring the impact of various compounds on RNA synthesis and cancer cell behavior, contributing to the understanding of gene regulation in stress and disease contexts.

Recent Grants

Grant: Open

Science for Life Lab Fellow

Open Date: 2020-12-01

Close Date: 2026-11-01

Grant: Close

Academy of Finland Postdoctoral Researcher

Open Date: 2019-09-01

Close Date: 2022-08-01

Positions (1)

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Anniina Vihervaara

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KTH Royal Institute of Technology

Doctoral Student in Molecular Genomics

Doctoral Student in Molecular Genomics at KTH Royal Institute of Technology This fully funded 4-year PhD position at KTH Royal Institute of Technology in Stockholm, Sweden, offers an exciting opportunity to investigate the mechanisms of RNA synthesis and genome regulation. The project is situated within the field of Biotechnology and focuses on understanding how chromatin architecture and transcription are coordinated during cellular stress, differentiation, and disease states, including infections and cancer. The research utilizes and develops advanced techniques to track RNA synthesis at nucleotide resolution, analyzing the roles of various RNA Polymerase complexes (RNA Pol I-III, mitochondrial RNA Pol, and viral RNA-directed RNA synthesis). The project involves genome-wide assessments in models of differentiation, stress, and disease, providing a comprehensive approach to understanding gene regulation in health and disease. The doctoral student will be supervised by Assistant Professor Anniina Vihervaara and will join a dynamic research environment at KTH, a leading international technical university. The position includes a monthly salary according to KTH's doctoral student salary agreement, full employee benefits, and access to excellent research facilities. Eligibility and Requirements: Applicants must hold a master's degree (or equivalent) in biosciences such as molecular biology, cell biology, virology, or medicine, or have completed at least 240 higher education credits (with at least 60 at the second-cycle level), or possess equivalent knowledge. Required skills include experience with molecular laboratory methods (DNA, RNA, protein analysis), cell culture, and genome analysis (sequencing libraries, fastq-files, sequence alignment, genome browsing). A good understanding of cellular mechanisms during differentiation, stress, or disease is essential. English proficiency equivalent to English B/6 is mandatory. Meriting skills include experience with microscopy (especially live cell or high-resolution), research with viruses or bacteria, and spatial analysis (spatial transcriptomics/proteomics). Personal qualities such as goal orientation, perseverance, independence, collaboration, professionalism, and analytical ability are also important. Application Process: Applications must be submitted through KTH's recruitment system by the deadline of April 2, 2026. Required documents include a CV, application letter (max 2 pages), diplomas, grades, language certificates, and representative publications or technical reports. All documents must be certified and translated into English or Swedish if not originally issued in these languages. Only those admitted to postgraduate education may be employed as a doctoral student. The position is full-time and temporary, with the possibility of renewal according to KTH regulations. KTH is committed to equality, diversity, and providing a creative and dynamic environment for research and education. The university offers attractive benefits and opportunities for professional growth. For further information, contact Assistant Professor Anniina Vihervaara at [email protected]. For more details and to apply, visit the official application page: KTH Application Portal .

6 months ago

Articles (6)

Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release

P-TEFb and CDK12 facilitate transcriptional elongation by RNA polymerase II. Given the prominence of both kinases in cancer, gaining a better understanding of their interplay could inform the design of novel anti-cancer strategies. While down-regulation of DNA repair genes in CDK12-targeted cancer cells is being explored therapeutically, little is known about mechanisms and significance of transcriptional induction upon inhibition of CDK12. We show that selective targeting of CDK12 in colon cancer-derived cells activates P-TEFb via its release from the inhibitory 7SK snRNP. In turn, P-TEFb stimulates Pol II pause release at thousands of genes, most of which become newly dependent on P-TEFb. Amongst the induced genes are those stimulated by hallmark pathways in cancer, including p53 and NF-κB. Consequently, CDK12-inhibited cancer cells exhibit hypersensitivity to inhibitors of P-TEFb. While blocking P-TEFb triggers their apoptosis in a p53-dependent manner, it impedes cell proliferation irrespective of p53 by preventing induction of genes downstream of the DNA damage-induced NF-κB signaling. In summary, stimulation of Pol II pause release at the signal-responsive genes underlies the functional dependence of CDK12-inhibited cancer cells on P-TEFb. Our study establishes the mechanistic underpinning for combinatorial targeting of CDK12 with either P-TEFb or the induced oncogenic pathways in cancer.

Year:

2023

Collaborators (8)

zhijia wang

University of Helsinki

FINLAND

Maria Vartiainen

University of Helsinki

FINLAND

Lea Sistonen

Åbo Akademi University

FINLAND

John Lis

Barbara McClintock Professor of Molecular Biology and Genetics

Cornell University

UNITED STATES

Bina Prajapati

University of Helsinki

FINLAND

Rocio Gomez-Pastor

Assistant Professor

University of Minnesota

UNITED STATES

Maria Sokolova

University of Helsinki

FINLAND

Matjaž Barborič

University of Helsinki

FINLAND
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