Danielle Benoit

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Lorry Lokey Department Chair and Professor of Bioengineering

University of Oregon
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About

Dr. Danielle Benoit is the Lorry Lokey Department Chair and Professor of Bioengineering at the University of Oregon, USA. Her research focuses on the design and optimization of advanced drug delivery systems, particularly using nanoparticle technology for tendon healing and bone-targeted therapies. She has contributed significantly to the field through her recent articles on biomaterials and nanotechnology applications in biomedical engineering.

Recent Grants

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Endothelial cell signaling in regeneration

Open Date: 2019-02-01

Close Date: 2021-01-01

Grant: Close

Engineered salivary gland tissue chips

Open Date: 2017-08-01

Close Date: 2019-07-31

Grant: Close

Engineered salivary gland tissue chips

Open Date: 2017-08-01

Close Date: 2019-07-31

Grant: Close

Longitudinal monitoring of bone fracture healing using diffuse optical and correlation tomography

Open Date: 2017-04-01

Close Date: 2022-08-01

Grant: Close

Salivary gland-specific radioprotection

Open Date: 2016-09-21

Close Date: 2018-06-20

Positions (1)

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Danielle Benoit

University Name
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University of Oregon

The Benoit Lab at the Knight Campus, University of Oregon, is seeking a Postdoctoral Scholar to join their innovative research team in the Department of Bioengineering. The lab focuses on developing next-generation tissue-engineered periosteum (TEP) to enhance the healing of challenging bone defects, integrating expertise in polymer chemistry, hydrogel design, stem cell biology, and in vivo models. The successful candidate will lead the synthesis of multifunctional materials, conduct mechanistic biological studies, and contribute to high-impact publications and proposals. This project is part of a broader mission to design advanced biomaterials using bottom-up approaches, with applications in regenerative medicine and therapeutic discovery. The lab environment offers exceptional intellectual and technical resources, individualized training in communication, entrepreneurship, and professional development, and access to state-of-the-art facilities. Applicants should hold a Ph.D. in chemistry, biology, engineering, or a related field, with demonstrated research productivity and laboratory experience in bioengineering or related disciplines. Strong communication skills are essential. Preferred qualifications include experience with grant writing, small animal surgery, musculoskeletal regeneration, histology, biomechanics, flow cytometry, and live animal imaging. All offers are contingent upon a successful background check. The University of Oregon provides a robust benefits package, including health insurance, retirement plans, and paid time off. The position is open until filled, with review of applications beginning February 20, 2026. Interested candidates should submit a CV and cover letter via the University of Oregon careers portal. The Benoit Lab is committed to diversity, equity, and inclusion, and encourages all qualified individuals to apply. Key research areas include biomaterials, polymer chemistry, tissue engineering, hydrogel design, stem cell biology, regenerative medicine, and therapeutic discovery. The lab is led by Professor Danielle Benoit, an expert in bioengineering and materials science.

8 months ago

Articles (19)

Year:

2025

Head and neck cancers (HNCs) rank as the sixth most common cancer globally and result in over 450 000 deaths annually. Despite considerable advancements in diagnostics and treatment, the 5-year survival rate for most types of HNCs remains below 50%. Poor prognoses are often attributed to tumor heterogeneity, drug resistance, and immunosuppression. These characteristics are difficult to replicate using in vitro or in vivo models, culminating in few effective approaches for early detection and therapeutic drug development. Organs-on-a-chip offer a promising avenue for studying HNCs, serving as microphysiological models that closely recapitulate the complexities of biological tissues within highly controllable microfluidic platforms. Such systems have gained interest as advanced experimental tools to investigate human pathophysiology and assess therapeutic efficacy, providing a deeper understanding of cancer pathophysiology. This review outlines current challenges and opportunities in replicating HNCs within microphysiological systems, focusing on mimicking the soft, glandular, and hard tissues of the head and neck. We further delve into the major applications of organ-on-a-chip models for HNCs, including fundamental research, drug discovery, translational approaches, and personalized medicine. This review emphasizes the integration of organs-on-a-chip into the repertoire of biological model systems available to researchers. This integration enables the exploration of unique aspects of HNCs, thereby accelerating discoveries with the potential to improve outcomes for HNC patients.

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2024

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2022

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2022

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2022

Collaborators (5)

Luiz Eduardo Bertassoni

Oregon Health & Science University

UNITED STATES
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Anne Nichols

Research Assistant Professor

University of Rochester Medical Center

UNITED STATES
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Marian Hettiaratchi

Assistant Professor

University of Oregon

UNITED STATES
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Cristiane Miranda Franca

Research Assistant Professor

Oregon Health & Science University

UNITED STATES
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Alayna E. Loiselle

-

UNITED STATES
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