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Femke Broere

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Prof. at Utrecht University

Utrecht University
Country flagNetherlands

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About

Prof. Femke Broere is a faculty member at Utrecht University in the Netherlands. Her research focuses on immunology and antimicrobial mechanisms, with recent articles exploring topics such as immune responses to SARS-CoV-2 in domestic cats, and the characterization of macrophages in dogs. She also investigates the immune modulation potential of various treatments, including liposomes and peptides, to address autoimmune diseases and improve outcomes in arthritis and osteoarthritis. Prof. Broere is dedicated to advancing the understanding of immune system interactions across different species.

Recent Grants

Grant: Close

tolDC therapy for RA

Open Date: 2018-01-01

Close Date: 2023-01-01

Grant: Close

Therapeutic peptide vaccines in rheumatoid arthritis; how to promote Treg functionality

Open Date: 2013-09-01

Close Date: 2016-09-01

Grant: Close

Co-inducers of stress protein as Treg inducing anti-inflammatory agents: a novel nutraceutical approach in rheumatic diseases

Open Date: 2011-09-01

Close Date: 2014-09-01

Positions (2)

Publisher
source

Lindert Benedictus

University Name
.

Utrecht University

This PhD position at Utrecht University focuses on improving immunity in neonatal piglets through the project “Betere Afweer voor Betere biggEn” (BABE). The research aims to bridge fundamental immunology and practical applications in the swine industry, targeting the health and welfare of newborn piglets whose survival and long-term vitality depend on early immune system development. The project combines both fundamental and applied research, centering on two main pillars: optimizing colostrum quality via maternal (sow) nutrition and evaluating early-life vaccination strategies. As a PhD candidate, you will design and execute research involving laboratory work and animal studies. Key tasks include developing assays to characterize colostrum and milk composition, performing immunological assays, implementing nutritional and vaccination interventions, and conducting advanced data analysis (including omics datasets). You will set up and coordinate animal studies, collect samples, process and analyze complex datasets, write scientific publications, and present results at national and international conferences. The project is a public-private partnership, and you will work in a multidisciplinary team with researchers from Utrecht University’s Faculty of Veterinary Medicine (division Farm Animal Health and division Infectious Diseases and Immunology), Wageningen BioVeterinary Research, and two major industrial partners. Your primary workplace will be at Utrecht University, with some activities at Wageningen BioVeterinary Research in Lelystad and at industrial partner locations. As a PhD student, you will be enrolled in the Utrecht Graduate School of Life Sciences, receiving training and guidance for research and professional development. Opportunities exist to co-supervise Master’s students and participate in teaching. The position offers a one-year contract with the possibility of extension to four years based on a positive assessment. Employment includes a permanent contract, a working week of 36–40 hours, a gross monthly salary between €3,059 and €3,881 (full-time), 8% holiday pay, and an 8.3% year-end bonus. Utrecht University provides additional schemes for professional development, leave, sports, and cultural activities, with flexible employment conditions. Applicants must hold a Master’s degree in Life Sciences (e.g., Veterinary Medicine, Animal Science, Infection and Immunity), have experience or interest in immunology and at least one of the following: swine industry, nutrition, or data analysis. Effective English communication skills are required, along with flexibility to work in different locations and a valid Category B driver’s license. The university values diversity and strives for an inclusive environment. To apply, submit your CV and a letter of motivation via the Utrecht University job portal by 27 May 2026. Interviews will take place at the end of June or beginning of July. For further information, contact Dr. Lindert Benedictus. This position provides an excellent foundation for an independent academic career in veterinary science, immunology, and animal health.

5 months ago

Publisher
source

Utrecht University

Utrecht University

Utrecht University is advertising a fully funded PhD position in Improving Immunity in Neonatal Piglets within the BABE project (“Betere Afweer voor Betere biggEn”). The project sits at the intersection of veterinary science , biology , immunology , nutrition , and public health , with a strong applied focus on animal welfare and sustainable livestock production. The research aims to improve the survival, vitality, and long-term health of newborn piglets by strengthening early immune development. The project has two main research pillars: optimizing colostrum quality through maternal (sow) nutrition, and evaluating early-life vaccination strategies. The work combines fundamental science with practical industry relevance and is carried out in a public-private partnership. As a PhD candidate, you will set up and coordinate animal studies, collect samples, develop and perform immunological assays, analyze complex omics datasets, and contribute to scientific publications and conference presentations. There are also opportunities to co-supervise Master’s students and participate in teaching. The project involves collaboration between Utrecht University, Wageningen BioVeterinary Research, and industrial partners. Eligibility highlights include a Master’s degree in Life Sciences such as Veterinary Medicine, Animal Science, or Infection and Immunity; interest or experience in immunology plus swine industry, nutrition, or data analysis; strong English communication skills; flexibility to work across multiple sites; and a valid Category B driver’s license. The position is based primarily at the Faculty of Veterinary Medicine at Utrecht University, with some work at Wageningen BioVeterinary Research in Lelystad and partner locations. The appointment is for one year initially, with the possibility of extension to a total of four years after a positive go/no-go assessment. The salary is €3,059 to €3,881 gross per month for full-time work, plus holiday pay and year-end bonus. The application deadline is 27 May 2026 . Applicants should submit a CV and motivation letter via the university application portal. Interviews are expected at the end of June or beginning of July 2026.

5 months ago

Articles (10)

Year:

2024

Year:

2023

Year:

2023

The binding of Host Defense Peptides (HDPs) to the endotoxin of Gram-negative bacteria has important unsolved aspects. For most HDPs, it is unclear if binding is part of the antibacterial mechanism or whether LPS actually provides a protective layer against HDP killing. In addition, HDP binding to LPS can block the subsequent TLR4-mediated activation of the immune system. This dual activity is important, considering that HDPs are thought of as an alternative to conventional antibiotics, which do not provide this dual activity. In this study, we systematically determine, for the first time, the influence of the O-antigen and Lipid A composition on both the antibacterial and anti-endotoxin activity of four HDPs (CATH-2, PR-39, PMAP-23, and PMAP36). The presence of the O-antigen did not affect the antibacterial activity of any of the tested HDPs. Similarly, modification of the lipid A phosphate (MCR-1 phenotype) also did not affect the activity of the HDPs. Furthermore, assessment of inner and outer membrane damage revealed that CATH-2 and PMAP-36 are profoundly membrane-active and disrupt the inner and outer membrane of Escherichia coli simultaneously, suggesting that crossing the outer membrane is the rate-limiting step in the bactericidal activity of these HDPs but is independent of the presence of an O-antigen. In contrast to killing, larger differences were observed for the anti-endotoxin properties of HDPs. CATH-2 and PMAP-36 were much stronger at suppressing LPS-induced activation of macrophages compared to PR-39 and PMAP-23. In addition, the presence of only one phosphate group in the lipid A moiety reduced the immunomodulating activity of these HDPs. Overall, the data strongly suggest that LPS composition has little effect on bacterial killing but that Lipid A modification can affect the immunomodulatory role of HDPs. This dual activity should be considered when HDPs are considered for application purposes in the treatment of infectious diseases.

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2020

Collaborators (11)

Marianna Tryfonidou

Professor at Utrecht University

Utrecht University

NETHERLANDS
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Jose L. Gonzales

Wageningen University & Research

NETHERLANDS
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Herman Egberink

associate professor

Utrecht University

NETHERLANDS
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Naomi Benne

Utrecht University

NETHERLANDS
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Nora M. Gerhards

Wageningen University & Research

NETHERLANDS
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Christine Jansen

Associate Professor

Wageningen University & Research

NETHERLANDS
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Edwin J. A. Veldhuizen

Utrecht University

NETHERLANDS
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Willem van Eden

Prof.

Utrecht University

NETHERLANDS
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Sandra Vreman

Wageningen University & Research

NETHERLANDS
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Victor PMG Rutten

Utrecht University

NETHERLANDS
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Alice Sijts

Associate Professor

Utrecht University

NETHERLANDS
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