Karl Carlström

Karolinska Institutet is seeking a postdoctoral researcher to join the Carlström lab in the Department of Laboratory Medicine, Division of Clinical Immunology. The lab focuses on dissecting the metabolic and epigenetic interplay in cells, particularly using iPSCs, primary cells, and animal models, with a special emphasis on oligodendroglia and their roles in regeneration and cancer. The research leverages advanced genome engineering tools, CRISPR-based technologies, and single-cell multi-omic profiling to unravel the mechanisms of subcellular protein compartmentalization and its impact on gene regulation and cell function. The successful candidate will be involved in iPSC culturing, genome/transcriptome/epigenome engineering, advanced single-cell profiling, proteomics, molecular cloning, viral transduction, flow cytometry, microscopy, and other molecular biology techniques. Responsibilities also include sharing research insights, supervising MSc and PhD students, and contributing to scientific publications and reports. Applicants must hold a doctoral degree in Molecular Biology, Biomedicine, Computational Biology, Bioinformatics, or a related field. Experience with molecular biology techniques, iPSC and organoid culture, genome engineering, and computational analysis of single-cell data is highly valued. Proficiency in English and strong communication skills are required. The scholarship is open only to foreign researchers who have not completed their academic education in Sweden, supporting internationalization and research qualification post-PhD. The postdoctoral scholarship is tax-free, awarded for up to two years, and paid in twelve-month periods (disbursed every six months). The application deadline is April 30, 2026. Applications must be submitted via the Varbi recruitment system and include a CV, publication list, and a summary of current work. For more information, contact Assistant Professor Karl Carlström at Karolinska Institutet.

Karolinska Institutet is advertising a PhD position in epigenetic and metabolic interplay in the Carlström laboratory. The project focuses on how subcellular protein and metabolite distribution shapes the chromatin landscape , with a strong emphasis on epigenetics , metabolism , protein biology , genome engineering , and single-cell multi-omics . The research environment is described as highly collaborative and well equipped, with access to state-of-the-art techniques and core facilities. The lab works with iPSCs , primary cells, and animal models, with a specific focus on glial cell biology , regeneration, and cancer. Methods mentioned include CRISPR-based genome/transcriptome/epigenome engineering, perturbation screens, Cut&Tag, ATAC-seq, proteomics, molecular cloning, viral transduction, flow cytometry, and microscopy. This is a doctoral studentship at Karolinska Institutet, offering a contractual salary for up to 4 years full-time. The position is suitable for candidates with training in Molecular Biology, Biomedicine, Computational Biology, Bioinformatics, or related fields. Prior experience with human iPSCs, organoids, genome engineering, and single-cell omics is a merit. Strong English proficiency is required. Eligibility requires a master’s degree or equivalent (including at least 240 credits with 60 advanced credits), plus English proficiency equivalent to English B/English 6. The application deadline is 2026-06-07 . Applicants should submit a motivation letter, CV, references, and supporting documents through the Varbi recruitment system.