Postdoc in Liposomal Cancer Vaccines and Immunology at Leiden University Medical Centre

Leiden University Medical Centre (LUMC) is offering a postdoctoral position in the Department of Immunology, focusing on the development of innovative liposomal cancer vaccines and intradermal vaccine delivery. The research is situated at the intersection of pharmaceutical technology and immunology, with a strong translational focus and collaboration with both academic and industrial partners. The successful candidate will join the Pharmaceutical Immunology group led by Dr. Koen van der Maaden. The main research topics include the development and optimization of cationic liposomal vaccine formulations containing cancer-specific peptides, with an emphasis on physicochemical characterization (size, charge, stability, encapsulation), and compatibility with intradermal injection devices. The work involves both in vivo studies in mice and ex vivo studies using human skin explants, as well as immune cell culture, analysis, and functional testing. The project aims to bridge fundamental and applied research, preparing vaccine formulations for future GMP compatibility and clinical application. Applicants should hold a PhD in (bio)pharmaceutical sciences, pharmaceutical technology, chemistry, or a closely related field. Required skills include experience in pharmaceutical formulation development (preferably lipid-based), affinity with cancer immunotherapy and vaccination strategies, and experience with cell culture and immune cell analysis. Interest in translational research and GMP-oriented development is essential. Candidates should demonstrate initiative, precision, collaborative skills, and a structured, goal-oriented approach to research. The position offers a gross monthly salary between €3,598 and €5,669 (scale 10 CAO UMC), with additional benefits such as an end-of-year bonus, holiday allowance, sports budget, bicycle scheme, home office allowance, commuting allowance, and participation in the ABP pension fund. LUMC provides a supportive, inclusive, and sustainable work environment with opportunities for personal and professional development. Applications are open for 17 more days. The selection process includes two interview rounds, with the second round requiring a presentation on your scientific work. For more information or to apply, visit the LUMC vacancies portal or contact Dr. Koen van der Maaden at [email protected].