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Leopold Eckhart

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Associate Professor

Medical University of Vienna

Austria

Research Interests

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Professors in Austria Professors in Cell Biology Cell Biology professors in Austria

About

Leopold Eckhart is an Associate Professor at the Medical University of Vienna, Austria. His research focuses on amino acid metabolism in the skin, the evolution of proteases, and the development of skin appendages. Recent publications highlight areas such as cellular differentiation, autophagy in keratinocytes, and the evolution of cornified epithelial structures in vertebrates.

Recent Grants

Grant: Open

Autonomous pigmentation of epithelial cells

Open Date: 2025-03-01

Close Date: 2029-02-28

Grant: Close

Molecular evolution of skin appendages

Open Date: 2023-03-01

Close Date: 2026-02-01

Grant: Close

Evolution of epidermal transglutamination

Open Date: 2020-01-01

Close Date: 2022-12-31

Grant: Close

Evolution of epidermal cornification proteins

Open Date: 2015-07-01

Close Date: 2018-06-30

Grant: Close

Characterization of age-related protein accumulation in autophagy-deficient neurons

Open Date: 2015-05-01

Close Date: 2016-12-01

Articles (35)

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2020

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2020

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2020

Collaborators (13)

Kris Vleminckx

Professor

Ghent University

BELGIUM

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Ionela Mariana Nagelreiter

Medical University of Vienna

AUSTRIA

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Wolfgang Sipos

University of Veterinary Medicine Vienna

AUSTRIA

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Elfride De Baere

BELGIUM

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Erwin Tschachler

Professor of Dermatology, Head of Research DIvision of Skin Biology and Pathobiology

Medical University of Vienna

AUSTRIA

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Patricia de la Cruz Ojeda

Instituto de Biomedicina de Sevilla

SPAIN

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Joanna Koziel

assistant professor

Jagiellonian University

POLAND

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Claudia Hess

Head

LVA GmbH

AUSTRIA

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Jordi Muntané

SPAIN

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Florian Gruber

Medical University of Vienna

AUSTRIA

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Walter Balduini

Professore Ordinario

Università degli Studi di Udine

ITALY

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Heinz Fischer

Medical University of Vienna

AUSTRIA

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Michal Mikula

Professor

Maria Sklodowska-Curie National Research Institute of Oncology

POLAND

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Leopold Eckhart

Research Interests

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About

Recent Grants

Articles (35)

Cell Death by Holocrine Secretion: The Final Step of Epithelial Differentiation in Sebaceous Glands

Hoxc13 and homologs of mammalian hair keratins are required for the cornification of nuptial pads in Xenopus frogs

Evolution of an amphibian-specific family of epidermal differentiation-associated genes

Comparative Genomics Reveals Recurrent Loss of Autophagy-Related 9B (ATG9B) in Amniotes

Amino Acid Metabolism of the Skin: Control by Specific Enzymes and Contribution to Protective Functions

Caspase-14-like Proteases: An Epidermal Caspase and Its Evolutionarily Ancient Relatives

Caspase Domain Duplication During the Evolution of Caspase-16

Cornified Epithelial Teeth of Jawless Vertebrates Contain Proteins Similar to Keratin-Associated Proteins of Mammalian Skin Appendages

Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair and Other Cornified Epithelial Structures

Convergent Evolution of Cysteine-Rich Keratins in Horny Teeth of Jawless Vertebrates and in Cornified Skin Appendages of Amniotes

Convergent Evolution Has Led to the Loss of Claw Proteins in Snakes and Worm Lizards

The Epithelial Egg Tooth of the Chicken Shares Protein Markers with the Embryonic Subperiderm and Feathers

Comparative Transcriptomics Reveals a Dual Role of the Epidermal Differentiation Complex in the Skin and the Oesophagus

Caspase-5: Structure, Pro-Inflammatory Activity and Evolution

Cell differentiation in the embryonic periderm and in scaffolding epithelia of skin appendages

Epidermal Differentiation Genes of the Common Wall Lizard Encode Proteins with Extremely Biased Amino Acid Contents

The Evolution of Transglutaminases Underlies the Origin and Loss of Cornified Skin Appendages in Vertebrates

MCPIP1 Controls the Effects of Myeloid Cells on Skin Carcinogenesis and Hair Growth

Comparative genomics of sirenians reveals evolution of filaggrin and caspase-14 upon adaptation of the epidermis to aquatic life

Letter to the Editor, “Autophagy Plays a Crucial Role in Ameloblast Differentiation”

Evolutionary origin of Hoxc13-dependent skin appendages in amphibians

Evolutionary origin of Hoxc13-dependent skin appendages in amphibians

Comparative immunohistochemical analysis suggests a conserved role of EPS8L1 in epidermal and hair follicle barriers of mammals

Identification of autophagy-regulated proteins by proteomic analysis of tape-stripped stratum corneum

Autophagy-Mediated Cellular Remodeling during Terminal Differentiation of Keratinocytes in the Epidermis and Skin Appendages

Iron Metabolism of the Skin: Recycling versus Release

Heme Oxygenase-1 Is Upregulated during Differentiation of Keratinocytes but Its Expression Is Dispensable for Cornification of Murine Epidermis

Differential Loss of OAS Genes Indicates Diversification of Antiviral Immunity in Mammals

Transglutaminase Activity Is Conserved in Stratified Epithelia and Skin Appendages of Mammals and Birds

Inactivation of Autophagy in Keratinocytes Reduces Tumor Growth in Mouse Models of Epithelial Skin Cancer

Identification of Chicken Transglutaminase 1 and In Situ Localization of Transglutaminase Activity in Avian Skin and Esophagus

The Trichohyalin-Like Protein Scaffoldin Is Expressed in the Multilayered Periderm during Development of Avian Beak and Egg Tooth

Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot.

ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging

Cell aging and cellular senescence in skin aging — Recent advances in fibroblast and keratinocyte biology

Collaborators (13)

Kris Vleminckx

Ionela Mariana Nagelreiter

Wolfgang Sipos

Elfride De Baere

Erwin Tschachler

Patricia de la Cruz Ojeda

Joanna Koziel

Claudia Hess

Jordi Muntané

Florian Gruber

Walter Balduini

Heinz Fischer

Michal Mikula

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