Lukas Sommer
Professor
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About
Professor Lukas Sommer is a faculty member at the University of Zurich, Switzerland. His research primarily focuses on cancer biology, particularly melanoma, and involves exploring therapeutic resistance mechanisms and innovative treatment approaches. Recent publications include studies on TGFβ signaling in melanoma, the role of macrophages in targeted therapy response, and the impact of neural crest cell factors on developmental pathways.
Positions (1)
Lukas Sommer
University of Zurich
University of Zurich is advertising an open postdoctoral position in skin morphogenesis in the laboratory of Prof. Lukas Sommer at the Institute of Anatomy . The project is part of the interdisciplinary SKINTEGRITY.CH consortium and focuses on neural crest stem cell biology , skin development , tissue repair , regeneration , and tumorigenesis . The research builds on recent findings that de-differentiated peripheral glia drive wound healing in adult skin and now aims to uncover how glial cells shape the skin microenvironment during development. The work combines single-cell , spatial , and functional approaches to map glial influences across diverse cell types and to study the transition from scarless to scarring repair. This is a fully funded postdoctoral position supported by the Swiss National Science Foundation . The appointment is available for at least 3 years and is based at the University of Zurich in Switzerland. Eligible candidates should hold a PhD, MD-PhD, or equivalent degree in the life sciences. The ideal profile includes a strong publication record, especially first-author papers in major journals, and experience with cell culture , genetic mouse models , functional genomics , and high-dimensional data analysis . Backgrounds in embryology and/or skin biology are highly desirable, along with the ability to work independently in an interdisciplinary environment. To apply, prepare a single PDF with your CV , publication list , motivation letter , and the names and email addresses of three references . Submit the application through the UZH job portal via the APPLY NOW button.
Articles (11)
Year:
2024
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2024
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2024
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2024
Metastatic disease is a major cause of death for patients with melanoma. Melanoma cells can become metastatic not only due to cell-intrinsic plasticity but also due to cancer-induced protumorigenic remodeling of the immune microenvironment. Here, we report that innate immune surveillance by natural killer (NK) cells is bypassed by human melanoma cells expressing the stem cell marker NGFR. Using in vitro and in vivo cytotoxic assays, we show that NGFR protects melanoma cells from NK cell–mediated killing and, furthermore, boosts metastasis formation in a mouse model with adoptively transferred human NK cells. Mechanistically, NGFR leads to down-regulation of NK cell activating ligands and simultaneous up-regulation of the fatty acid stearoyl–coenzyme A desaturase (SCD) in melanoma cells. Notably, pharmacological and small interfering RNA–mediated inhibition of SCD reverted NGFR-induced NK cell evasion in vitro and in vivo. Hence, NGFR orchestrates immune control antagonizing pathways to protect melanoma cells from NK cell clearance, which ultimately favors metastatic disease.
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2023
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2023
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2022
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2022
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2022
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2022
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2021
Collaborators (5)
Jess G. Snedeker
Balgrist University Hospital
Corinne Tanchot
Université Paris Cité
Amro Hussien
Max Planck Institute of Molecular Physiology
Himeka Hayashi
Okayama University
Julie Refardt
University Hospital Basel
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