Maruti Uppalapati

Assistant Professor

University of Saskatchewan

Canada

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Maruti Uppalapati is an Assistant Professor at the University of Saskatchewan, Canada. His research primarily focuses on the development of innovative optogenetic tools and therapeutic strategies for cancer treatment, as evidenced by his recent articles on antibody-drug radioconjugates and theranostics. He is particularly interested in the interaction of radiolabeled antibodies with tumor microenvironments and the pharmacokinetics of engineered antibody variants.

Maruti Uppalapati

Research Interests

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Articles (17)

Optimized Phage Display-Based Selection for the Development of Heterodimerizing Optogenetic Tools

An Anti-EGFR Antibody-Drug Radioconjugate Labeled with Actinium-225 Elicits Durable Anti-Tumor Responses in KRAS and BRAF Mutant Colorectal Cancer.

Effects of binding partners on thermal reversion rates of photoswitchable molecules

225Ac/89Zr-Labeled N4MU01 Radioimmunoconjugates as Theranostics Against Nectin-4-Positive Triple-Negative Breast Cancer.

Initial insights into the interaction of antibodies radiolabeled with Lutetium-177 and Actinium-225 with tumor microenvironment in experimental human and canine osteosarcoma.

Efficacy of [67Cu]Cu-EB-TATE Theranostic Against Somatostatin Receptor Subtype-2-Positive Neuroendocrine Tumors.

Preclinical safety and effectiveness of a long-acting somatostatin analogue [225Ac]Ac-EBTATE against small cell lung cancer and pancreatic neuroendocrine tumors.

Comparative Molecular Characterization and Pharmacokinetics of IgG1-Fc and Engineered Fc Human Antibody Variants to Insulin-like Growth Factor 2 Receptor (IGF2R)

Image-Based Dosimetry in Dogs and Cross-Reactivity with Human Tissues of IGF2R-Targeting Human Antibody

Engineering of bidirectional, cyanobacteriochrome-based light-inducible dimers (BICYCL)s

Engineering of a Fully Human Anti-MUC-16 Antibody and Evaluation as a PET Imaging Agent

Radioimmunotherapy Targeting IGF2R on Canine-Patient-Derived Osteosarcoma Tumors in Mice and Radiation Dosimetry in Canine and Pediatric Models

The EphB6 Receptor: Kinase-Dead but Very Much Alive

Novel Human Antibodies to Insulin Growth Factor 2 Receptor (IGF2R) for Radioimmunoimaging and Therapy of Canine and Human Osteosarcoma

A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.

Structure-based design of a photoswitchable affibody scaffold

Yeast Two-Hybrid Screening of Photoswitchable Protein-Protein Interaction Libraries.

Collaborators (4)

Ekaterina Dadachova

Hannes Beyer

Humphrey Fonge

Andrew Woolley

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