Mats Larhed

Professor

Uppsala Universitet Farmaceutiska fakulteten

Sweden

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Professor Mats Larhed is a faculty member at Uppsala Universitet Farmaceutiska fakulteten in Sweden. His research focuses on the development of novel inhibitors targeting insulin-regulated aminopeptidase (IRAP) and the synthesis of nonnatural amino acids. Recent articles include investigations into peptidomimetics and the application of various synthetic methodologies to enhance the understanding of pharmaceutical compounds.

Mats Larhed

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Articles (16)

Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations

A Diastereoselective Mizoroki–Heck Reaction for Synthesis of Spirooxindole-Based Nonnatural Amino Acids Using a Boc-Protected Amine Chiral Auxiliary

Novel macrocyclic peptidomimetics targeting the insulin-regulated aminopeptidase (IRAP): design, synthesis and evaluation

The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds

Inhibition of Insulin-Regulated Aminopeptidase by Imidazo [1,5-α]pyridines—Synthesis and Evaluation

Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells

Two-Chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles

Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Diastereoselective Synthesis of N-Methylspiroindolines by Intramolecular Mizoroki–Heck Annulations

Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2)

18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand

Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer—Optimization of the Affinity towards PSMA by Linker Modification in Murine Model

Regio- and Stereoselective Synthesis of Allylic Spiroethers (Spirobenzofuranes) via an Intramolecular Mizoroki–Heck Reaction

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro‐Oxindole Dihydroquinazolinones as IRAP Inhibitors

Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP)

Collaborators (10)

Anastasia Mpakali

Johan Gising

Ulrika Rosenström

Alfhild Grönbladh

Petros Giastas

Christian Sköld

Mathias Hallberg

Luke R. Odell

Sherry L. Mowbray

Lawrence Stern

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