Michelle Williams

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Assistant Professor

University of Pittsburgh
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United States

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Recent Grants

Grant: Open

Targeting heme metabolism to initiate an immune response against breast cancer liver metastasis

Open Date: 2022-08-01

Close Date: 2027-08-01

Grant: Close

Impact of heme catabolism on triple negative breast cancer metastasis via immune-suppression

Open Date: 2020-01-01

Close Date: 2021-06-01

Grant: Close

Heme catabolism supports triple negative breast cancer progression

Open Date: 2018-07-01

Close Date: 2019-12-01

Grant: Close

Mcl-1 drives resistance of luminal breast cancers to targeted therapies

Open Date: 2015-05-01

Close Date: 2017-08-01

Positions (1)

Articles (10)

The underappreciated role of resident epithelial cell populations in metastatic progression: contributions of the lung alveolar epithelium

Metastatic cancer is difficult to treat and is responsible for the majority of cancer-related deaths. After cancer cells initiate metastasis and successfully seed a distant site, resident cells in the tissue play a key role in determining how metastatic progression develops. The lung is the second most frequent site of metastatic spread, and the primary site of metastasis within the lung is alveoli. The most abundant cell type in the alveolar niche is the epithelium. This review will examine the potential contributions of the alveolar epithelium to metastatic progression. It will also provide insight into other ways in which alveolar epithelial cells, acting as immune sentinels within the lung, may influence metastatic progression through their various interactions with cells in the surrounding microenvironment.

Year:

2022

Collaborators (4)

Jennifer K. Richer

University of Colorado Anschutz Medical Campus

UNITED STATES

James Costello

Associate Professor

University of Colorado School of Medicine

UNITED STATES

Allison Porman Swain

Assistant Professor

United States Air Force Academy

UNITED STATES

Jill Slansky

University of Colorado School of Medicine

UNITED STATES
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