Michelle Williams
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Assistant Professor
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Recent Grants
Grant: Open
Targeting heme metabolism to initiate an immune response against breast cancer liver metastasis
Open Date: 2022-08-01
Close Date: 2027-08-01
Grant: Close
Impact of heme catabolism on triple negative breast cancer metastasis via immune-suppression
Open Date: 2020-01-01
Close Date: 2021-06-01
Grant: Close
Heme catabolism supports triple negative breast cancer progression
Open Date: 2018-07-01
Close Date: 2019-12-01
Grant: Close
Mcl-1 drives resistance of luminal breast cancers to targeted therapies
Open Date: 2015-05-01
Close Date: 2017-08-01
Articles (10)
The underappreciated role of resident epithelial cell populations in metastatic progression: contributions of the lung alveolar epithelium
Metastatic cancer is difficult to treat and is responsible for the majority of cancer-related deaths. After cancer cells initiate metastasis and successfully seed a distant site, resident cells in the tissue play a key role in determining how metastatic progression develops. The lung is the second most frequent site of metastatic spread, and the primary site of metastasis within the lung is alveoli. The most abundant cell type in the alveolar niche is the epithelium. This review will examine the potential contributions of the alveolar epithelium to metastatic progression. It will also provide insight into other ways in which alveolar epithelial cells, acting as immune sentinels within the lung, may influence metastatic progression through their various interactions with cells in the surrounding microenvironment.
Year:
2022
Collaborators (4)
Jennifer K. Richer
University of Colorado Anschutz Medical Campus
James Costello
Associate Professor
University of Colorado School of Medicine
Allison Porman Swain
Assistant Professor
United States Air Force Academy
Jill Slansky
University of Colorado School of Medicine

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