Mitchell Elliott

The Elliott Lab at Yale University , within the Center for Breast Cancer at Yale Cancer Center and Yale School of Medicine, is recruiting a Postdoctoral Associate in translational oncology . Led by Mitchell Elliott (Assistant Professor of Medicine, Medical Oncology), the lab studies the molecular evolution of drug resistance in breast cancer , with a focus on topoisomerase-1 inhibitor antibody-drug conjugates (TOP1i-ADCs) . The position combines wet-lab cancer biology with clinically oriented translational research. Core activities include mammalian cell culture, cloning, plasmid preparation, gene editing, functional phenotyping, in vitro and in vivo drug efficacy assays, patient-derived xenograft (PDX) models, and development/validation of circulating tumor DNA (ctDNA) and liquid biopsy technologies. Computational analysis is not required but is strongly encouraged, especially for multi-omic data such as structural variants and transcriptomics using R or Python pipelines. Applicants must hold a Ph.D., M.D., or equivalent doctoral degree in cancer biology, molecular and cellular biology, genetics, pharmacology, or a closely related field. The post emphasizes prior experience in oncology, drug resistance, molecular biology, mammalian cell culture, and rigorous experimental design. Experience with PDX models, ctDNA assays, UNIX, or bioinformatic pipelines is highly desirable. A strong publication record, communication skills, and the ability to work independently and collaboratively are expected. The role offers close mentorship from Dr. Elliott and the multidisciplinary Yale breast oncology team, with support for manuscript preparation, grant writing, presentations, and career development toward an independent clinician-scientist or research path. Compensation is $68,500 or commensurate with experience, and the preferred start date is October 1, 2026 . Applications are reviewed until the position is filled. To apply, send a cover letter , CV , and contact information for three references to [email protected] . In the cover letter, briefly describe your bench research experience, computational interests (if any), relevant expertise for the Elliott Lab, and long-term career goals.