Nobuhiko Tokuriki

Professor

The University of British Columbia

Canada

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Professor Nobuhiko Tokuriki is a faculty member at the University of British Columbia in Canada. His research focuses on protein evolution, antibiotic resistance, and microbial metabolic evolution, as highlighted in his recent publications. His work employs both computational and experimental approaches to investigate protein fitness landscapes and the dynamism of epistatic networks.

Nobuhiko Tokuriki

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Articles (25)

Functional sub-states link conformational landscapes and protein evolution

Stability of multi-species consortia during microbial metabolic evolution

Molecular Evolution and Origins of Antibiotic Resistance Genes

Exploring Large Protein Sequence Space through Homology- and Representation-based Hierarchical Clustering

Computational and Experimental Exploration of Protein Fitness Landscapes: Navigating Smooth and Rugged Terrains

Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design

Author Correction: Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase

Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase

Rapid evolutionary change in trait correlations of single proteins

Neutral drift upon threshold-like selection promotes variation in antibiotic resistance phenotype

Author Correction: Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning

Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning

Genetic Perturbation Alters Functional Substates in Alkaline Phosphatase

Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution

Evolution of new metabolic pathways and microbial communities

Molecular determinants of protein evolvability

Environmental selection and epistasis in an empirical phenotype–environment–fitness landscape

Evolution of β-lactamase-mediated cefiderocol resistance

Insertions and Deletions (Indels): A Missing Piece of the Protein Engineering Jigsaw.

The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis.

Epistasis and intramolecular networks in protein evolution.

Evolution of β-lactamases and enzyme promiscuity.

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections.

Statistical analysis of mutational epistasis to reveal intramolecular interaction networks in proteins.

A mechanistic view of enzyme evolution.

Collaborators (8)

Ørjan Samuelsen

Kazuhito Tabata

Malcolm D. McLeod

Francesco Zamponi

Marc van der Kamp

Rory Little

Hiroshi Ueno

Douglas Fowler

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