Papireddy Kancharla

Portland State University is offering a PhD position in Chemistry, with a focus on medicinal and synthetic organic chemistry. The opportunity is announced by Research Associate Professor Papireddy Kancharla, whose lab specializes in developing natural product–inspired anti-infective agents through structure-activity relationship (SAR) studies, lead optimization, and mechanism-of-action research. The Kancharla laboratory is dedicated to discovering and developing next-generation antimalarial agents capable of targeting multiple stages of the Plasmodium parasite life cycle, aiming to overcome emerging drug resistance. Their research also extends to innovative therapeutic leads for leishmaniasis, fungal, bacterial, and cancer diseases. The lab offers a highly collaborative and interdisciplinary environment, encouraging students with strong backgrounds in organic or medicinal chemistry to apply. The team has pioneered the discovery of natural product-inspired antimalarial chemotypes, such as tambjamines and prodiginines, which show potent multi-stage activity and promise for preventing relapsing liver-stage infections. Current projects involve extensive structural optimization to identify candidates for preclinical development. Applicants should have a solid foundation in organic or medicinal chemistry and an interest in drug discovery and synthetic chemistry. The position is open for Fall 2026, and candidates must meet the graduate admission requirements of Portland State University's Chemistry PhD program. While no specific funding details are provided, prospective students are encouraged to explore the program and reach out to Professor Kancharla for further information. Application details and lab information can be found on the university and lab websites. For more information, visit the Kancharla Lab page and the Portland State University admissions portal. This is an excellent opportunity for students passionate about medicinal chemistry, organic synthesis, and global health challenges to join a dynamic research group in a supportive academic environment.