Sebastien Gagneux

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Professor & Head of Department

Swiss Tropical and Public Health Institute

Switzerland

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Professor Sebastien Gagneux is the Head of Department at the Swiss Tropical and Public Health Institute in Switzerland. His research predominantly focuses on the ecology, diversity, and evolutionary mechanisms of the Mycobacterium tuberculosis complex, as well as its genetic variations and resistance profiles. Recent publications include studies on antimicrobial activities, transmissibility differences, and the genetic basis of drug resistance in tuberculosis strains.

Recent Grants

Grant: Open

The virulence-transmission trade-off: exploring the biological determinants and epidemiological consequences of subclinical tuberculosis

Open Date: 2023-01-01

Close Date: 2027-01-01

Grant: Open

PANGenS - Pan-Africa network for genomic surveillance of poverty related diseases and emerging pathogens

Open Date: 2023-01-01

Close Date: 2027-01-01

Grant: Close

Linking within-host and between-host evolution in multidrug-resistant Mycobacterium tuberculosis

Open Date: 2020-01-01

Close Date: 2025-01-01

Grant: Close

Population genomic and phenotypic determinants of host tropism in the Mycobacterium tuberculosis Complex affecting livestock and humans

Open Date: 2019-01-01

Close Date: 2023-01-01

Grant: Close

Host-pathogen genomic interactions and their phenotypic impact in human tuberculosis

Open Date: 2018-01-01

Close Date: 2022-01-01

Sebastien Gagneux

Research Interests

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About

Recent Grants

Articles (28)

Linking genetic and phenotypic bedaquiline resistance in Mycobacterium tuberculosis strains from Georgia

Ecology, global diversity and evolutionary mechanisms in the Mycobacterium tuberculosis complex

Transmission as a Key Driver of Resistance to the New Tuberculosis Drugs.

Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis

Granulysin Antimicrobial Activity Promotes Dormancy in Mycobacterium tuberculosis.

Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania

Onset of infectiousness explains differences in transmissibility across Mycobacterium tuberculosis lineages

Gene conversion and duplication contribute to genetic variation in an outbreak of Mycobacterium tuberculosis

Mycobacteria beyond disease

A successful UN High-Level Meeting on antimicrobial resistance must build on the 2023 UN High-Level Meeting on tuberculosis

Genetic Characterization and Population Structure of Drug-Resistant Mycobacterium tuberculosis Isolated from Brazilian Patients Using Whole-Genome Sequencing

Diagnostic accuracy of a sequence-specific <i>Mtb</i> -DNA hybridization assay in urine: a case-control study including subclinical TB cases

HIV co-infection is associated with reduced Mycobacterium tuberculosis transmissibility in sub-Saharan Africa

Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania

A Genome-Focused Investigation Reveals the Emergence of a Mycobacterium tuberculosis Strain Related to Multidrug-Resistant Tuberculosis in the Amazon Region of Brazil

Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a 2023 TBnet/RESIST-TB consensus statement.

Lack of methoxy-mycolates characterizes the geographically restricted lineage 7 of Mycobacterium tuberculosis complex

Macrophage susceptibility to infection by Ghanaian Mycobacterium tuberculosis complex lineages 4 and 5 varies with self-reported ethnicity

Effect of compensatory evolution in the emergence and transmission of rifampicin-resistant Mycobacterium tuberculosis in Cape Town, South Africa: a genomic epidemiology study

The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot

Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania

Evaluation of Nanopore sequencing for Mycobacterium tuberculosis drug susceptibility testing and outbreak investigation: a genomic analysis

Analysis of drug resistance among difficult-to-treat tuberculosis patients in Ghana identifies several pre-XDR TB cases

Key Contributions by the Swiss Tropical and Public Health Institute Towards New and Better Drugs for Tropical Diseases.

Bedaquiline resistance in patients with drug-resistant tuberculosis in Cape Town, South Africa: a retrospective longitudinal cohort study

How do monomorphic bacteria evolve? The Mycobacterium tuberculosis complex and the awkward population genetics of extreme clonality

Balancing access to BPaLM regimens and risk of resistance

Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis

Collaborators (14)

Susanna Brighenti

Helen Cox

Amanda Ross

Matthias Merker

Galo Goig

Russell Kempker

Johannes Nemeth

Nino Maghradze

Manuel W. Hetzel

Stephen Gordon

Daire Cantillon

Christian Beisel

Cyril Gaudin

Daniela Brites

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