Serena Ghisletti

The IEO European Institute of Oncology in Milan, Italy, is offering a 3-year fully funded postdoctoral position in the Department of Experimental Oncology, under the supervision of Serena Ghisletti. This opportunity is part of the EP PerMed project, focusing on 'Precision Medicine for Therapy-Related Myeloid Neoplasms.' The research will center on the integration and analysis of multi-omics data (including RNA-seq, ChIP-seq, ATAC-seq) to investigate transcriptional programs, cell heterogeneity, and the interplay between transcriptional circuits and epigenetic states in myeloid neoplasms. Key responsibilities include evaluating and implementing advanced bulk and single-cell RNA-seq workflows, developing and maintaining sequencing data processing pipelines on high-performance computing systems, and identifying patient-specific signatures by correlating longitudinal single-cell data with clinical outcomes. The position requires a PhD in bioinformatics, computational biology, systems biology, or a related field, with experience in NGS and omics data analysis, strong computational/statistical skills (Unix, Python, R/Bioconductor), and handling large-scale biological datasets. Additional skills in workflow management (Nextflow, Snakemake), single-cell/spatial omics analysis (Seurat, Scanpy), machine learning, AI, and containerization tools (Docker, Singularity) are highly valued. The successful candidate will join a dynamic team at IEO, contributing to cutting-edge research in precision medicine and oncology. The position is fully funded for three years, with support from the European Partnership for Personalised Medicine. Interested candidates should submit their CV to Serena Ghisletti at [email protected]. For more information, candidates can review the EP PerMed project details and contact the supervisor directly.

We’re hiring for a Computational Postdoc at the European Institute of Oncology (IEO) in Milan, Italy, within the EP PerMed project on Precision Medicine for Therapy-Related Myeloid Neoplasias . This postdoctoral opportunity sits at the intersection of computational biology , bioinformatics , genomics , medical science , and translational oncology . The successful candidate will work in the team of Serena Ghisletti and contribute to research on transcriptional programs, cell heterogeneity, and patient stratification in a large cohort of myeloid neoplasms. Key research tasks include analysis of bulk RNA-seq , single-cell RNA-seq , and spatial transcriptomics ; integration of multi-omics data such as RNA-seq , ChIP-seq , and ATAC-seq ; development and maintenance of sequencing data processing pipelines on HPC systems; and identification of patient-specific signatures linked to clinical outcomes. Required background includes a PhD in bioinformatics, computational biology, systems biology, or a related field, plus experience in NGS and omics data analysis. Strong skills in Unix , Python , and R/Bioconductor are expected. Preferred experience includes Nextflow or Snakemake , Seurat or Scanpy , machine learning/AI, and containerization with Docker or Singularity . The position is offered for 3 years . No stipend amount, tuition coverage, or formal deadline is stated in the post. Interested candidates should email their CV to Serena Ghisletti at [email protected] .

Postdoctoral position available at the European Institute of Oncology (IEO), Milan, Italy , in the team of Serena Ghisletti , Professor of Biochemistry. This opportunity is part of the EP PerMed-funded PRECISION-tMN project, focused on therapy-related myeloid neoplasms (t-MN) and the molecular mechanisms driving disease development, progression, and therapeutic resistance. The project combines epigenomics , transcriptomics , and single-cell technologies to study patient-derived samples, with methods including scRNA-seq , scATAC-seq , and ChIP-seq . The broader project framework also emphasizes precision medicine, multi-omics analysis, biomarker discovery, therapeutic target identification, and translational oncology. Candidate profile: applicants should hold a PhD in molecular biology, molecular medicine, cancer biology, biotechnology, genetics, or a related area. The post requires strong skills in advanced biochemical, molecular, and cell biology techniques, plus excellent organizational, communication, and collaborative abilities. The ideal candidate is highly self-motivated, scientifically curious, proactive, and able to develop independent research projects. English proficiency for speaking and writing is required. Funding and duration: the position is offered for one year , renewable up to three years , within the EP PerMed project framework. No stipend amount is stated in the post. Application: candidates should apply through the IEO application page and may also send their CV to Serena Ghisletti at the email provided in the post. The post was published on 5 June 2026 .