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Tomoki IGUCHI

Assistant Professor

Tokyo University of Pharmacy and Life Sciences

Japan

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Research Interests

Pharmaceutical Chemistry

40%

Pharmacology

90%

Phytochemical

100%

Natural Products Chemistry

60%

Cytotoxicity

50%

Terpenoid Chemistry

50%

Ethnopharmacology

50%

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Recent Grants

Grant: Close

非内因性経路に着目した植物由来サポニンのアポトーシス誘導メカニズムの解明

Open Date: 2022-04-01

Close Date: 2025-03-31

Grant: Close

Elucidation of induction of apoptosis by steroidal glycosides via a mitochondria-independent pathway

Open Date: 2019-08-30

Close Date: 2021-03-31

Articles15

Apoptosis-inducing activity of a steroidal glycoside from Allium chinense G. Don. bulbs in human small-cell lung cancer cells via mitochondrial dysfunction and ER stress

Article Link

Year:

2025

Agapanthussaponin A from the Underground Parts of Agapanthus africanus Induces Apoptosis and Ferroptosis in Human Small-Cell Lung Cancer Cells

Article Link

Year:

2025

Structural determination of two undescribed triterpenoids from Punica granatum L. peels

Article Link

Year:

2025

Quantitative analyses of sennosides A and B in eight ethical bofutsushosan extract products

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Year:

2024

Steroidal glycosides from Ornithogalum thyrsoides bulbs and their cytotoxicity toward HL-60 human promyelocytic leukemia cells and SBC-3 human small-cell lung cancer cells

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Year:

2024

Six unprecedented steroidal glycosides from Allium atropurpureum bulbs and their cytotoxicities against SBC-3 human small-cell lung cancer cells

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Year:

2023

Determination of Structure and Cytotoxicity of Ten Undescribed Steroidal Glycosides from <i>Allium cristophii</i> × <i>A. macleanii</i> ‘Globemaster’

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Year:

2023

Hesperetin Ameliorates Inhibition of Neuronal and Oligodendroglial Cell Differentiation Phenotypes Induced by Knockdown of Rab2b, an Autism Spectrum Disorder-Associated Gene Product

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Year:

2023

Chemical constituents and aldose reductase inhibitory activities of Betula alba bark and leaves

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Year:

2022

Novel Oleanane-Type Triterpene Glycosides from the Saponaria officinalis L. Seeds and Apoptosis-Inducing Activity via Mitochondria

Article Link

Year:

2022

Structure Elucidation of 16 Undescribed Steroidal Glycosides from the Underground Parts of Agapanthus africanus and Apoptosis-Inducing Activity in Small-Cell Lung Cancer Cell

Article Link

Year:

2022

Three novel furospirostanol glycosides and a steroidal alkaloid glycoside from the bulbs of Fritillaria camtschatcensis (L.) Ker Gawl., and their cytotoxicity

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Year:

2022

A new and 23 known cardenolide glycosides from Thevetia neriifolia seeds and their cytotoxic activities against human oral carcinoma cell lines

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Year:

2021

Bufadienolides and ecdysteroids from the whole plants of Helleborus niger and their cytotoxicity

Article Link

Year:

2021

Steroidal Glycosides from the Aerial Parts of Avena sativa L. And Their Cytotoxic Activity

Article Link

Year:

2021

Collaborators1

Junji Yamauchi

Tokyo University of Pharmacy and Life Sciences

JAPAN

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