Ville Paakinaho
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Assistant Professor (tenure track)
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About
Ville Paakinaho is an Assistant Professor (tenure track) at the University of Eastern Finland. His research focuses on molecular mechanisms in prostate cancer, particularly the interactions of androgen and glucocorticoid receptors, as well as metabolic reprogramming in associated diseases. Recent publications also explore the role of SUMOylation and the impact of matrix stiffness on gene expression and cell plasticity in cancer cells. He contributes significantly to understanding the transcriptional responses and signaling pathways that influence cancer development and progression.
Recent Grants
Grant: Close
Drug resistance-induced reprogramming of chromatin and transcription factor activity in prostate cancer
Open Date: 2021-09-01
Close Date: 2026-08-01
Grant: Close
Drug resistance-induced reprogramming of chromatin and transcription factor activity in prostate cancer (funding for research costs)
Open Date: 2021-09-01
Close Date: 2024-12-01
Grant: Close
Reprogramming Chromatin Occupancy and Transcriptional Activity by Dynamic Transcription Factor Transitions
Open Date: 2018-01-09
Close Date: 2021-08-31
Articles (22)
SIX2 promotes cell plasticity via Wnt/β-catenin signalling in androgen receptor independent prostate cancer
The use of androgen receptor (AR) inhibitors in prostate cancer gives rise to increased cellular lineage plasticity resulting in resistance to AR-targeted therapies. In this study, we examined the chromatin landscape of AR-positive prostate cancer cells post-exposure to the AR inhibitor enzalutamide. We identified a novel regulator of cell plasticity, the homeobox transcription factor SIX2, whose motif is enriched in accessible chromatin regions after treatment. Depletion of SIX2 in androgen-independent PC-3 prostate cancer cells induced a switch from a stem-like to an epithelial state, resulting in reduced cancer-related properties such as proliferation, colony formation, and metastasis both in vitro and in vivo. These effects were mediated through the downregulation of the Wnt/β-catenin signalling pathway and subsequent reduction of nuclear β-catenin. Collectively, our findings provide compelling evidence that the depletion of SIX2 may represent a promising strategy for overcoming the cell plasticity mechanisms driving antiandrogen resistance in prostate cancer.
Year:
2024
Collaborators (12)
Tapio Visakorpi
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Markku Varjosalo
University of Helsinki
Christopher Jarzynski
Distinguished University Professor
University of Maryland at College Park
Jorma Palvimo
Professor of Medical Biochemisty
University of Eastern Finland
Lorenzo Rinaldi
Head of Translational Science
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Gordon Hager
Chief
National Cancer Institute
Karolien De Bosscher
Full professor
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Sonia Kung
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Daniel Wüstner
University of Southern Denmark
Liza Dewyse
Vrije Universiteit Brussel
Einari Niskanen
University Lecturer at University of Eastern Finland
University of Eastern Finland
Kirsi Ketola
University of Eastern Finland

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