Yuki Goto

Associate Professor

University of Tokyo

Japan

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Dr. Yuki Goto is an Associate Professor at the University of Tokyo, Japan. His research focuses on the chemoenzymatic synthesis, discovery, and characterization of macrocyclic peptides, particularly those involved in bioactive applications. Recent contributions include advancements in genetic coding for peptide discovery and the application of deep learning in library design for bioactive compounds.

Yuki Goto

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Articles (18)

Chemoenzymatic Synthesis and in Vitro Selection of De Novo Thiazole‐Containing Macrocyclic Peptides

A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides

De Novo Discovery of Pseudo‐Natural Prenylated Macrocyclic Peptide Ligands

De Novo Discovery of Pseudo‐Natural Prenylated Macrocyclic Peptide Ligands

Oxidation-guided and collision-induced linearization assists de novo sequencing of thioether macrocyclic peptides

Modulating the Acceptor Preference of His‐C‐Geranyltransferase LimF

Label-free quantification of passive membrane permeability of cyclic peptides across lipid bilayers: penetration speed of cyclosporin A across lipid bilayers

Deep Learning-Driven Library Design for the De Novo Discovery of Bioactive Thiopeptides

Switching Prenyl Donor Specificities of Cyanobactin Prenyltransferases

De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors

Post-translational backbone-acyl shift yields natural product-like peptides bearing hydroxyhydrocarbon units

Solid-Phase-Based Synthesis of Lactazole-Like Thiopeptides

Accurate Models of Substrate Preferences of Post-Translational Modification Enzymes from a Combination of mRNA Display and Deep Learning

New developments in RiPP discovery, enzymology and engineering

Discovery and Development of Cyclic Peptide Inhibitors of CIB1

The RaPID Platform for the Discovery of Pseudo-Natural Macrocyclic Peptides

Site-Specific Nonenzymatic Peptide S/O-Glutamylation Reveals the Extent of Substrate Promiscuity in Glutamate Elimination Domains

Posttranslational chemical installation of azoles into translated peptides

Collaborators (8)

Naohiro Terasaka

Elke Dittmann

Kazuhito Tabata

Toru Sengoku

Manuel Montalbán López

Hiroaki Suga

Alexander Vinogradov

Jumpei Morimoto

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