Sarcoma UK PhD studentship

This PhD project, funded by the Sarcoma UK PhD studentship, aims to identify novel biomarkers and therapeutic targets in primary breast angiosarcoma (PBA) using innovative iPSC-derived endothelial models. PBA is a rare and aggressive vascular tumour with poor prognosis and limited treatment options, affecting younger individuals and lacking established clinical management protocols. The project addresses critical gaps in understanding the molecular mechanisms driving PBA, focusing on the frequent co-occurring mutations in PIK3CA and KDR genes that are unique to this disease subtype.

The successful candidate will establish the first genetically defined human iPSC-derived endothelial models of PBA and perform spatial molecular profiling of patient tissues. The research will integrate experimental and clinical data to uncover actionable diagnostic markers and therapeutic strategies. Using inducible gene expression systems and advanced lineage barcoding, the student will model PIK3CA and KDR mutations alone and in combination, within arterial and venous endothelial contexts. These models will be used to define early transformation events, identify signalling dependencies, and evaluate targeted combination therapies with clinically relevant agents.

The training provided is comprehensive and interdisciplinary, covering precision disease modelling, genetic engineering, advanced 2D and 3D vascular model systems, high-content imaging, single-cell signalling analysis, quantitative proteomics, spatial transcriptomics, and drug screening. The student will also gain experience in computational multi-omic data integration, clinical and international research collaboration, and patient engagement through Sarcoma UK. Unique features include direct interaction with clinician-scientists, participation in an international research network, and training in responsible science communication and impact-driven research design.

The position is based at the Cancer Research UK Beatson Institute, within the Cell Biology of Cancer department, and is affiliated with the University of Glasgow. The studentship provides a generous annual tax-free stipend (£22,500 plus indexation), and covers tuition fees at the home or international rate. Applicants should have a strong academic background in biological sciences, genetics, or a related field, with experience in cell or molecular biology and an interest in cancer research. Both UK and international students are eligible to apply.

The application deadline is April 24, 2026. For further information or queries regarding the application process, contact phdstudentships@crukscotlandinstitute.ac.uk.