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University of St Andrews

Funded PhD in Design, Synthesis, and Mechanism of Action of DNPH1 Inhibitors University of St Andrews in United Kingdom

Degree Level

PhD

Field of study

Biochemistry

Funding

This is a 4-year competition-funded PhD project through EASTBIO BBSRC Doctoral Training Partnership. It is open to UK and international students and provides a stipend at the UKRI standard rate plus UK tuition fees; the University of St Andrews covers the Home-International fee difference.

Deadline

Nov 16, 2026

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Country

United Kingdom

University

University of St Andrews

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Keywords

Biochemistry
Chemistry
Biomedical Engineering
Organic Chemistry
Biology
Structural Biology
Chemical Biology
Pharmaceutical Chemistry
Enzyme Inhibition

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About this position

PhD opportunity at the University of St Andrews in the School of Biology / School of Chemistry, working on design, synthesis, and mechanism of action of inhibitors of the human enzyme DNPH1 (2′-deoxynucleoside 5′-phosphate N-hydrolase 1).

This project sits at the interface of Biochemistry, Structural Biology, Medicinal Chemistry, Organic Synthesis, and Chemical Biology. DNPH1 is a nucleotide-sanitizing enzyme, and the project aims to design potent and selective inhibitors and elucidate how they work mechanistically. The student will gain experience in structure- and mechanism-based inhibitor design, synthesis of small molecules, spectroscopic characterisation, enzyme kinetics, and analysis of inhibition mechanisms.

The project is hosted in the Biomedical Sciences Research Complex (BSRC), a collaborative research environment with state-of-the-art infrastructure for structural biology, enzymology, molecular biophysics, NMR, HPLC, MS, crystallisation, and access to major facilities such as Diamond Light Source and ESRF.

Eligibility highlights: applicants should have a 1st-class degree in Chemistry with a focus on Medicinal Chemistry. Practical experience in organic synthesis and chemical biology is preferred. The opportunity is open to UK and international students.

Funding: this is a 4-year competition-funded PhD through the EASTBIO BBSRC Doctoral Training Partnership. Funding covers a stipend at the UKRI standard rate and UK tuition fees; the University of St Andrews covers the Home-International fee difference.

How to apply: complete the EASTBIO Equality, Diversity and Inclusion survey and the EASTBIO Application Form, then submit an online application via the University of St Andrews portal. Select PhD with internship and upload the required documents, including qualifications, English language evidence if applicable, and two references.

Application contact: queries on the project can be directed to the supervisors; application questions can be sent to Rachel Horn at [email protected].

Funding details

This is a 4-year competition-funded PhD project through EASTBIO BBSRC Doctoral Training Partnership. It is open to UK and international students and provides a stipend at the UKRI standard rate plus UK tuition fees; the University of St Andrews covers the Home-International fee difference.

What's required

Applicants should have a 1st-class degree in Chemistry with a focus on Medicinal Chemistry. Hands-on experience in organic synthesis and chemical biology is preferred. English language qualification is required if applicable, and applicants must meet EASTBIO/University of St Andrews eligibility guidance.

How to apply

Download and complete the EASTBIO Equality, Diversity and Inclusion survey and the EASTBIO Application Form. Submit an online application through the University of St Andrews portal and select the course 'PhD with internship'. Include the EASTBIO form, academic qualifications, English language qualification if applicable, and two references on the EASTBIO reference form.

More information can be found here

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