PhD Studentships in Medicinal Chemistry, Chemical Biology, and Structural Biophysics University of Strathclyde in United Kingdom

Coming soon at the Astbury Centre for Structural Molecular Biology, The University of Leeds: two postdoctoral positions and one PhD position will soon be advertised. The research themes mentioned are outer membrane protein assembly mechanisms and cryoEM of amyloid. One postdoc and one PhD student will be linked to outer membrane protein assembly mechanisms, while one postdoc will focus on cryoEM of amyloid. The post is shared by Sheena Radford, Astbury Professor of Biophysics at The University o...

PhD opportunity at the University of St Andrews in the School of Biology / School of Chemistry, working on design, synthesis, and mechanism of action of inhibitors of the human enzyme DNPH1 (2′-deoxynucleoside 5′-phosphate N-hydrolase 1). This project sits at the interface of Biochemistry , Structural Biology , Medicinal Chemistry , Organic Synthesis , and Chemical Biology . DNPH1 is a nucleotide-sanitizing enzyme, and the project aims to design potent and selective inhibitors and elucidate how ...

PhD opportunity at Cardiff University in chemical biology , medicinal chemistry , and drug discovery , focused on developing selective chemical probes for TFEB/TFE3. The project aims to uncover the distinct roles of TFEB and TFE3 in lysosomal gene regulation and to study the consequences of inhibiting these transcription factors. The research combines biochemical and cellular assay development, high-throughput screening, computational chemistry, and structure-guided medicinal chemistry to discov...

CNRS Research Director Anton Granzhan is recruiting for an 18-month postdoctoral position in bioorganic chemistry and chemical biology at LCBPT (CNRS – Université Paris Cité, Paris, France). The project builds on a recent discovery of small molecules that selectively bind DNA three-way junctions and show toxicity against certain cancer cells. The next stage is to design a new generation of macrocyclic TWJ ligands and heterobifunctional probes to investigate how these molecules act in cells. Suit...

Funded PhD project at the University of Edinburgh on peptide-based precision anti-infectives for the prophylaxis and prevention of foodborne listeriosis . The project focuses on Listeria monocytogenes , a major foodborne pathogen, and explores a novel anti-virulence strategy targeting the bacterial regulator PrfA . Building on structural and functional discoveries from the Vázquez-Boland group, the PhD will design, synthesise, and evaluate peptide-based PrfA inhibitors as potential Listeria-targ...