Newcastle University
1 week ago
Funded PhD in Immune Dysfunction, RNA Polymerase III, and tRNA-Related Gene Defects Newcastle University in United Kingdom
Degree Level
PhD
Field of study
Cell Biology
Funding
Funded PhD project. MRC CoRE-TG scholarship, if nominated, provides course fees for the duration of fee liability, a living stipend at the UKRI rate for four years, a £20,000 Research Training Support Grant, and a £1,200 travel allowance. Only UK national students are eligible for this scholarship route.
Country
United Kingdom
University
Newcastle University
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About this position
PhD project at Newcastle University on immune dysfunction in patients with combined immunodeficiency caused by RNA polymerase III and tRNA-related gene defects.
You will investigate how defects in RNA transcription, processing, and translation affect immune homeostasis, with a strong focus on cell biology, genetics, genomics, molecular biology, and molecular genetics. The project includes CRISPR/Cas9 gene editing, functional assays in T- and B-cell lines, RNA sequencing, translation analysis, and bioinformatic analysis in R.
Research activities include introducing disease-causing variants by gene editing, measuring T-cell proliferation and activation, assessing B-cell differentiation, quantifying tRNA abundance and maturation, and correcting patient cells by CRISPR to restore function. The project aims to clarify disease mechanisms and support future precision therapies.
The project is based in Newcastle, United Kingdom. It is advertised as a funded PhD project for students worldwide, with an MRC CoRE-TG scholarship route available for UK national students only. Scholarship support may include fees, a UKRI-rate stipend for four years, a £20,000 RTSG, and a £1,200 travel allowance.
Applications are accepted all year round. Interested applicants should register their interest via the FindAPhD page and follow the host department/university admissions requirements. For programme questions, contact [email protected].
Funding details
Funded PhD project. MRC CoRE-TG scholarship, if nominated, provides course fees for the duration of fee liability, a living stipend at the UKRI rate for four years, a £20,000 Research Training Support Grant, and a £1,200 travel allowance. Only UK national students are eligible for this scholarship route.
What's required
Applicants should meet the admissions requirements of the relevant host department or university. The project is aimed at PhD candidates and involves work on combined immunodeficiency, gene editing, RNA biology, immunology, genomics, and bioinformatic analysis in R. The MRC CoRE-TG scholarship route is limited to UK national students due to UKRI international recruitment limits.
How to apply
Register your interest for the project through the FindAPhD page. For programme questions, contact [email protected]. Applications are assessed by the host department or university admissions requirements.
More information can be found here
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