University of Oxford
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Funded PhD in Mapping and Editing Gene Regulatory Networks for Therapies for Genetic Disorders University of Oxford in United Kingdom
Degree Level
PhD
Field of study
Cell Biology
Funding
Funded PhD project. The MRC CoRE-TG DPhil scholarship, if awarded, covers course fees for the duration of fee liability, a living stipend at the UKRI rate for four years, a £20,000 Research Training Support Grant, and a £1,200 travel allowance. The project is described as funded for students worldwide, but the named scholarship route is restricted to UK national students.
Deadline
Dec 1, 2026
Country
United Kingdom
University
University of Oxford
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About this position
PhD opportunity at the Radcliffe Department of Medicine, University of Oxford in Oxford, United Kingdom.
This project, Mapping and Editing Gene Regulatory Networks to Develop Therapies for Genetic Disorders, focuses on genomics, human genetics, molecular genetics, functional genomics, cell biology, and genetic engineering. The research aims to understand how inherited diseases can arise from variants in regulatory DNA rather than only from mutations in protein-coding genes.
The student will use Micro Capture-C to map three-dimensional chromatin interactions across haematological and neurological tissues, linking disease-associated variants to target genes and pathways. Candidate regulatory elements will then be tested using high-throughput CRISPR screening and other functional genomic approaches, including ChIP-seq, ATAC-seq, and RNA-seq. The project also includes bioinformatic analysis of these datasets and working with Genomics England data.
Training opportunities include molecular techniques, chromosome conformation capture, CRISPR cloning and cell culture, possible single-cell technologies, and bioinformatics analysis of functional genomics data. The project is designed for students interested in translating basic genomic discovery into potential therapies for genetic disorders.
Funding is available through the MRC CoRE-TG DPhil scholarship, which may cover fees, a UKRI-rate stipend for four years, a £20,000 RTSG, and a £1,200 travel allowance. Note that this scholarship route is restricted to UK national students because of UKRI limits on international recruitment, even though the project itself is listed as funded for students worldwide.
Applications are competitive and will be assessed according to the admissions requirements of the host department or university. Interested applicants should register their interest via the FindAPhD listing and contact [email protected] with questions about the programme.
Funding details
Funded PhD project. The MRC CoRE-TG DPhil scholarship, if awarded, covers course fees for the duration of fee liability, a living stipend at the UKRI rate for four years, a £20,000 Research Training Support Grant, and a £1,200 travel allowance. The project is described as funded for students worldwide, but the named scholarship route is restricted to UK national students.
What's required
Applicants should meet the admissions requirements of the relevant host department or university. The project is suitable for students interested in genomics, human genetics, molecular genetics, functional genomics, CRISPR screening, chromatin biology, and bioinformatics. The post notes that the student will develop bioinformatic skills to analyse Micro Capture-C, ChIP-seq, ATAC-seq, and RNA-seq data. The MRC CoRE-TG scholarship route is limited to UK national students due to UKRI international recruitment limits.
How to apply
Register your interest for the project through the FindAPhD page. For programme questions, contact [email protected]. Applications will be assessed against the admissions requirements of the host department or university, and shortlisted candidates may have a second interview for the scholarship route.
More information can be found here
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