Publisher
source

Masaryk University

Funded PhD in Intratumoral Heterogeneity in Cellular Response to p53 and ISR Activation Masaryk University in Czech Republic

Degree Level

PhD

Field of study

Cell Biology

Funding

Primary funding for the proposed work is secured by AZV award NW25-03-00134 to the supervisor. The PhD program requires students to have at least 25,000 CZK per month in financial support, typically from a combination of grants and scholarships.

Deadline

Nov 30, 2026

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Country

Czech Republic

University

Masaryk University

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Keywords

Cell Biology
Cancer Biology
Medicine
Biology
Single-cell Analysis
Medical Science
Bioscience
Spatial Transcriptomic
Biomedicine

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About this position

Funded PhD project at Masaryk University, Faculty of Medicine in Brno, Czechia.

The project is titled “Intratumoral heterogeneity in cellular response to p53 and ISR activation” and sits in the Doctoral study program Biomedical Sciences, Department of Biology. The research focuses on cancer biology, cell biology, and translational tumor response mechanisms, especially p53, the integrated stress response (ISR), MDM2 inhibitors, and eIF2a inhibitors.

The project aims to understand why some tumor cell subpopulations resist combined pharmacological activation of p53 and ISR pathways. Planned methods include single-cell RNA-seq, spatial transcriptomics, IHC, orthotopic colorectal cancer tumor models, and bioinformatic transcriptome analysis. The work is designed to identify resistant subpopulations and test strategies to sensitize them in vitro and in vivo.

Funding: primary research funding is secured by AZV award NW25-03-00134 to the supervisor. The doctoral program requires students to have at least 25,000 CZK/month in financial support, usually from combined sources such as grants and scholarships.

Eligibility highlights: minimum publication activity during the PhD is one first-author publication with IF above the field median or two first-author publications in Q3 journals. A foreign internship of at least 1 month is required, and students will also participate in teaching.

Location: Brno, Czechia. Deadline shown on the listing: 2026-11-30.

Funding details

Primary funding for the proposed work is secured by AZV award NW25-03-00134 to the supervisor. The PhD program requires students to have at least 25,000 CZK per month in financial support, typically from a combination of grants and scholarships.

What's required

Doctoral study program in Biomedical Sciences. The student must have financial support of at least 25,000 CZK per month from combined sources. Minimum publication activity required during the PhD is one first-author publication with IF above the field median or two first-author publications in Q3 journals. A foreign internship of at least 1 month is mandatory, and the student will also participate in teaching.

How to apply

Review the project details and use the FindAPhD application route or institution website to apply. Check the project page for the full application process and contact the supervisor if needed.

More information can be found here

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