Masaryk University
1 month ago
Funded PhD in Mechanism of Cell Death Induced by Joint Activation of p53 and ISR Networks Masaryk University in Czech Republic
Degree Level
PhD
Field of study
Cell Biology
Funding
Funded PhD project supported by the GACR project 25-18368S and internal laboratory sources. PhD students must have financial support of at least 25,000 CZK per month, typically from a combination of grants and scholarship sources.
Deadline
Nov 30, 2026
Country
Czech Republic
University
Masaryk University

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About this position
PhD opportunity at Masaryk University, Faculty of Medicine, Brno, Czechia. The project is titled Mechanism of the cell death induced by joint activation of p53 and ISR networks and is hosted in the Department of Biology within the doctoral study program Biomedical Sciences.
This funded PhD focuses on cancer biology, cell biology, and genomics, with a strong molecular mechanism angle. The research investigates how joint activation of the p53 and ISR pathways triggers cell death in cancer cells, with emphasis on transcriptional regulation by p53, ATF4, and XBP1. Planned work includes mapping transcription factor occupancy in multiple CRC cell lines and using genome-wide CRISPR screens and RNA-seq to identify mediators of apoptosis/cell death induced by combined MDM2 and eIF2a inhibition.
Funding is supported by the GACR project 25-18368S and internal laboratory sources. The program notes that PhD students must have financial support of at least 25,000 CZK per month, usually from a combination of grants and scholarship sources.
Eligibility highlights include the doctoral board’s publication expectations: at least one first-author publication above the field median or two first-author publications in Q3 journals by the end of the degree. Students are also expected to complete a foreign internship of at least one month and participate in teaching.
The deadline shown on the listing is 2026-11-30. Interested applicants should review the project page, read the linked background article, and follow the institution’s application instructions for the doctoral position.
Funding details
Funded PhD project supported by the GACR project 25-18368S and internal laboratory sources. PhD students must have financial support of at least 25,000 CZK per month, typically from a combination of grants and scholarship sources.
What's required
Applicants should be suitable for doctoral study in Biomedical Sciences and be able to meet the doctoral board requirement of at least one first-author publication above the field median or two first-author Q3 publications by completion. The program requires financial support of at least 25,000 CZK per month from combined sources. Students must complete a foreign internship of at least 1 month and participate in teaching.
How to apply
Visit the FindAPhD listing and follow the institution website/application route for the doctoral position. Review the project details and funding requirements before applying. Contact the supervisor or department if additional application instructions are needed.
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