MRC Laboratory of Medical Sciences
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Funded PhD in Sex-specific Immune Responsiveness and TLR7/8 Biology MRC Laboratory of Medical Sciences in United Kingdom
Degree Level
PhD
Field of study
Cell Biology
Funding
Funded PhD studentship covering all tuition fees plus a tax-free stipend of £26,500 per year paid monthly. Funding is available for both Home and Overseas students.
Country
United Kingdom
University
MRC Laboratory of Medical Sciences
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About this position
Funded PhD project at the MRC Laboratory of Medical Sciences (LMS) in London, United Kingdom on sex-specific immune responsiveness, with a strong focus on immunology, genetics, molecular biology, bioinformatics, cell biology, and developmental biology.
The project, supervised by Prof Matthias Merkenschlager and Dr Lila Allou, investigates why females are often better able to cope with some infections yet are more prone to autoimmune disease. The research centers on Toll-like receptors (TLR7/8), X-linked immune genes, X chromosome inactivation, epigenetic regulation, gene-environment interactions, age-related inflammation, and B cell clone dynamics.
Students will explore whether elevated TLR7 expression in XX immune cells is driven by active regulation or erosion of X-linked silencing, using long-read sequencing and genetic polymorphisms to distinguish between mechanisms. The project also examines downstream signaling pathways, ligand abundance, antagonism between TLRs, and how genetic variation and BCR specificity shape immune cell competitiveness and disease susceptibility.
This is a funded PhD studentship open to students worldwide. Funding covers all tuition fees and includes a tax-free stipend of £26,500 per year, paid monthly. The funding is available for both Home and Overseas students.
To apply, follow the LMS studentships application instructions and submit the required application form via the LMS website. The post notes that registering interest on FindAPhD is not an application.
Funding details
Funded PhD studentship covering all tuition fees plus a tax-free stipend of £26,500 per year paid monthly. Funding is available for both Home and Overseas students.
What's required
Applicants should follow the LMS application instructions and submit an application form by the deadline. The project is open to students worldwide and funding is available for both Home and Overseas students. The post does not specify additional academic requirements, but the research involves immunology, genetics, molecular biology, bioinformatics, long-read sequencing, and analysis of X-linked gene regulation and B cell biology.
How to apply
Go to the LMS studentships page linked in the post, follow the application instructions, and submit the application form by the deadline. Registering interest on FindAPhD is not considered an application.
More information can be found here
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