Sanquin
2 months ago
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PhD Candidate in Antibody Therapy for Bleeding Disorders Sanquin Blood Supply Foundation in Netherlands
Degree Level
PhD
Field of study
Computer Science
Funding
The position is a 4-year PhD employment contract at Sanquin with salary and conditions according to CAO Sanquin. Benefits mentioned include an 8.33% end-of-year bonus (thirteenth month for full-year employment), partial reimbursement of travel costs, a pension plan with PFZW, and 201 hours of leave per year at full-time employment (36 hours).
Deadline
Aug 28, 2026
Country
Netherlands
University
Sanquin

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About this position
Sanquin Blood Supply Foundation in Amsterdam, Netherlands is recruiting a PhD candidate for a 4-year project on antibody therapy for bleeding disorders. The work sits in Sanquin’s Division of Research and Lab Services and is embedded in a multidisciplinary team spanning protein engineering, immunoglobulin research, cellular hemostasis, and proteomics.
The project aims to develop coagulation factor mimetics using novel antibody formats that can arrest bleeding. Research topics include computational de novo design of VHH and scFv binders to coagulation factors such as factor Xa and prothrombin, wet-lab production and screening of binders, optimization of heterobispecific Fc formats with a focus on humanization and stability, and generation of high-affinity minibinders through in silico affinity maturation.
Supervision and collaboration involve Dr. Matti Pronker, Prof. Gestur Vidarsson, Prof. Jan Voorberg, and Dr. Maartje van den Biggelaar at Sanquin in Amsterdam. The post is especially suitable for candidates with experience in AI-based protein design and/or structural biology, and it is framed as a translational synthetic biology project in an international, academically oriented environment.
Funding and benefits include salary and conditions according to CAO Sanquin, an end-of-year bonus, partial travel reimbursement, pension coverage, and leave entitlement. The application deadline is 28 August 2026 at 21:59 UTC, and applicants are asked to submit an extended CV via the AcademicTransfer application page.
Funding details
The position is a 4-year PhD employment contract at Sanquin with salary and conditions according to CAO Sanquin. Benefits mentioned include an 8.33% end-of-year bonus (thirteenth month for full-year employment), partial reimbursement of travel costs, a pension plan with PFZW, and 201 hours of leave per year at full-time employment (36 hours).
What's required
Applicants should be highly motivated PhD candidates with an interest in translational synthetic biology and research on blood-related disorders. Experience in AI-based protein design and/or structural biology is particularly invited, and the project expects the student to contribute unique expertise to a multidisciplinary team. The post is for a PhD student position lasting 4 years.
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