Publisher
source

University of Poitiers

PhD in Cancer Mechanobiology and Mechanosensitive Calcium Channels at University of Poitiers University of Poitiers in France

Degree Level

PhD

Field of study

Pharmacology

Funding

3-year PhD contract. The post does not specify stipend amount or tuition coverage.

Deadline

Oct 1, 2026

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Country

France

University

University of Poitiers

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Keywords

Pharmacology
Chemistry
Biomedical Engineering
Biophysics
Biology
Medical Science
Cell Migration
Pharmacy
Metastasis
Pharmaceutical Chemistry
Drug Screening
In Vivo Imaging

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About this position

PhD opportunity in cancer mechanobiology at the 4CS Laboratory, University of Poitiers, France, focused on the development of novel mechanosensitive calcium channel modulators for controlling solid tumor metastatic dissemination.

The project aims to understand how calcium-permeable mechanosensitive channels contribute to cancer cell migration, invasion, phenotypic plasticity, and metastasis, and to screen/optimize selective inhibitors as potential anti-metastatic agents.

Research methods include cell and mechanobiology (2D/3D culture, wound healing, xCELLigence migration/invasion assays), calcium biology (FlexStation3 assays, live calcium videomicroscopy, mechanosensitivity assays), medicinal chemistry and computational virtual screening, biophysics & pharmacology (dose-response profiling, microscale thermophoresis), and in vivo imaging using zebrafish xenograft models.

Eligibility highlights: Master’s degree or equivalent in pharmacology, cell biology, cancer biology, biochemistry, or a related field; strong bench skills in cell culture and standard molecular biology techniques; interest in cancer research, medicinal chemistry, mechanotransduction, and ion channel biology. Experience in ion channels or drug discovery is a plus, and animal experimentation accreditation is preferred.

Funding/contract: 3-year PhD contract. The post does not specify stipend amount or tuition details.

Application: start date indicated as October 1st 2026 / Fall 2026. Applicants should email CV, cover letter, and two reference letters to [email protected] with the subject line PhD Application – Mechanosensitive Channels.

Funding details

3-year PhD contract. The post does not specify stipend amount or tuition coverage.

What's required

Master’s degree or equivalent in pharmacology, cell biology, cancer biology, biochemistry, or a related area. Strong interest in cancer research, medicinal chemistry, molecular mechanisms of tumor initiation and progression, mechanotransduction, and ion channel biology. Solid bench expertise in cell culture and basic lab experimentation such as Western blot and qPCR is required. Experience in ion channels or drug discovery is a plus. Accreditation for animal experimentation is preferred. The candidate should be enthusiastic, motivated, rigorous, reliable, able to work in multidisciplinary settings, and willing to interact with different collaborators.

How to apply

Send your CV, cover letter, and two reference letters to [email protected]. Use the subject line "PhD Application – Mechanosensitive Channels".

More information can be found here

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