The Francis Crick Institute
1 week ago
PhD in Determinants of Clonal Fitness in SF3B1-Mutant Clonal Haematopoiesis The Francis Crick Institute in United Kingdom
Degree Level
PhD
Field of study
Molecular Biology
Funding
Funded PhD project. Successful applicants will receive a non-taxable annual stipend of £27,715 plus payment of university tuition fees. Students of all nationalities are eligible to apply.
Country
United Kingdom
University
The Francis Crick Institute
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About this position
PhD opportunity at The Francis Crick Institute in London, United Kingdom on Determinants of Clonal Fitness in SF3B1-Mutant Clonal Haematopoiesis.
This funded PhD project with Dominique Bonnet explores how SF3B1 mutations drive clonal fitness in clonal haematopoiesis, with a strong focus on stem cell biology, RNA splicing, epigenetics, and the ageing bone marrow niche. The project aims to define the molecular mechanisms that give mutant haematopoietic stem cells a competitive advantage, understand how cooperating mutations such as DNMT3A and TET2 shape clonal expansion, and test how the bone marrow microenvironment influences mutant clone behaviour.
The work will use genetically edited human HSPCs, iPS lines, induced human haematopoietic stem cell models, and humanised niche systems in vivo. It is designed to uncover pathways that regulate clonal expansion and identify biomarkers and therapeutic targets relevant to progression toward myeloid malignancies.
Funding: successful applicants receive a non-taxable annual stipend of £27,715 plus university tuition fees. The project is open to students of all nationalities.
Eligibility: applicants with a background in biomedical sciences are encouraged to apply, especially those with experience in stem cell biology, gene editing, and/or iPS cell culture.
Application note: the listing includes a lab-specific question asking what aspect of the lab’s research you would explore further and what perspective, skill, or approach you would bring.
Funding details
Funded PhD project. Successful applicants will receive a non-taxable annual stipend of £27,715 plus payment of university tuition fees. Students of all nationalities are eligible to apply.
What's required
Candidates with a background in biomedical sciences are encouraged to apply. Knowledge and experience in stem cell biology, gene editing, and/or culture of iPS cells are preferred. Applicants should be able to engage with a research question on clonal haematopoiesis and contribute relevant experimental skills.
How to apply
Review the project details and answer the lab-specific question in your application. Apply through the FindAPhD listing or the institution's application route if provided on the project page.
More information can be found here
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