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University of Edinburgh

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PhD in Developing a Luciferase Reporter Platform for Testing RNA Therapies in Human Renal Tubular Cells University of Edinburgh in United Kingdom

Degree Level

PhD

Field of study

Biomedical Engineering

Funding

Competition-funded EASTBIO BBSRC DTP PhD studentship. Funding covers stipend and UK-level tuition fees; the University of Edinburgh covers the difference between home and international fees, so the studentship is fully funded for all appointees. There is a cap on the number of international students recruited.

Deadline

Nov 16, 2026

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Country

United Kingdom

University

University of Edinburgh

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Keywords

Biomedical Engineering
Biology
High-throughput Screening
Medical Science
Pharmacy
Rna Therapeutics

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About this position

PhD opportunity at the University of Edinburgh in RNA therapeutics, renal tubular cell biology, and luciferase reporter assay development.

This EASTBIO/BBSRC Doctoral Training Partnership project focuses on building a stable, quantitative screening platform to test RNA therapies in human renal tubular cells. The work aims to solve a key bottleneck in RNA medicine: rapidly and sensitively measuring whether an RNA therapeutic has entered the target cell and silenced its intended gene. The project combines lentiviral transduction, reporter line engineering, siRNA delivery, and high-throughput screening to compare RNA therapeutic formulations, including transfection reagents and lipid-based carriers.

You will work with the commercially available rpTEC-TERT1 cell line and a novel human renal tubular cell line, assessing reporter stability, sensitivity, dynamic range, and specificity. The project is embedded in ongoing Kidney Research UK-funded research on protecting cells from drug-induced nephrotoxicity, so the broader biomedical context is kidney protection and RNA-based chemoprotective strategies.

Training includes lentiviral vector biology, cell line generation, reporter assay validation, RNA therapeutics, lipid nanoparticle delivery systems, and quantitative cell biology. A flexible PIPS industry placement may be available, with CPI suggested as one option for exposure to RNA therapy development and lipid nanoparticle workflows.

Funding: competition-funded EASTBIO BBSRC DTP studentship. The post states it is open to UK and international students and provides stipend plus UK tuition fees; Edinburgh covers the home/international fee difference, making it fully funded for appointees, subject to international recruitment caps and UKRI eligibility rules.

How to apply: submit the EASTBIO Application Form and academic transcripts (PDF) to [email protected]. Referees should send references using the EASTBIO reference form template to the same email by 16 November 2026.

Funding details

Competition-funded EASTBIO BBSRC DTP PhD studentship. Funding covers stipend and UK-level tuition fees; the University of Edinburgh covers the difference between home and international fees, so the studentship is fully funded for all appointees. There is a cap on the number of international students recruited.

What's required

Applicants should be suitable for a 4-year PhD project in biological sciences and related biomedical research. The post mentions UK and international students and asks applicants to check UKRI Annex B eligibility criteria for funded studentships. A strong interest in RNA therapeutics, cell biology, reporter assays, lentiviral methods, and quantitative/high-throughput screening would be relevant. Applicants must submit the EASTBIO application form and academic transcripts, and arrange referee references by the deadline.

How to apply

Complete the EASTBIO Application Form and send it with a PDF copy of your academic transcripts to [email protected]. Ask your referees to submit references using the EASTBIO reference form template to the same email address. Do this by the application deadline of 16 November 2026.

More information can be found here

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