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University of Edinburgh

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PhD in Engineering Human CYP Reporter Hepatocytes for Screening Xenobiotic Metabolism Disruption University of Edinburgh in United Kingdom

Degree Level

PhD

Field of study

Chemistry

Funding

4-year funded PhD studentship funded by the EASTBIO BBSRC Doctoral Training Partnership. Funding covers a stipend and UK-level tuition fees; the University of Edinburgh covers the difference between home and international fees, making the studentship fully funded for appointees, though international places are capped.

Deadline

Nov 16, 2026

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Country

United Kingdom

University

University of Edinburgh

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Keywords

Chemistry
Environmental Science
Biomedical Engineering
Biology
Toxicology
Regenerative Medicine
High-throughput Screening
Medical Science
Pharmacy
Dietary Supplements

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About this position

PhD opportunity at the University of Edinburgh in the School of Regeneration and Repair (College of Medicine and Veterinary Medicine): EASTBIO: Engineering Human CYP Reporter Hepatocytes as Non-Animal Platforms to Screen Environmental and Dietary Xenobiotic Metabolism Disruption.

This project sits at the intersection of biology, biomedical engineering, chemistry, environmental science, pharmacy, and translational medical science. The research focuses on human hepatocytes, cytochrome P450 (CYP) enzymes, xenobiotic metabolism, endocrine disruption, and the development of non-animal screening systems for pesticides, dietary supplements, and other chemicals.

The project aims to engineer pre-cHep lines with dual fluorescent reporters under endogenous promoters for CYP3A4 paired with either CYP1A2 or CYP2B6, using modified CRISPR/Cas9 knock-in methods. The resulting reporter lines will be validated against known CYP inducers and then used to build a robust high-throughput screening platform for chemical libraries. The work is designed to support safer chemical development and regulatory compliance while reducing reliance on animal testing.

Training includes advanced 2D and 3D mammalian cell culture, precise genome editing, and optimization of image-based screening assays. The project is especially relevant for students interested in liver biology, toxicology, regenerative medicine, and industrial screening applications.

Funding: 4-year EASTBIO BBSRC DTP studentship. Funding covers stipend and UK-level tuition fees; the University of Edinburgh covers the difference between home and international fees, so the award is described as fully funded for successful applicants, subject to international recruitment caps.

Eligibility: Open to UK and international students, subject to UKRI/EASTBIO criteria.

How to apply: Submit the EASTBIO Application Form and academic transcripts (PDF) by email to [email protected]. Referees should send references using the EASTBIO reference form template to the same address.

Deadline: 16 November 2026.

Funding details

4-year funded PhD studentship funded by the EASTBIO BBSRC Doctoral Training Partnership. Funding covers a stipend and UK-level tuition fees; the University of Edinburgh covers the difference between home and international fees, making the studentship fully funded for appointees, though international places are capped.

What's required

Applicants should have or expect a strong background relevant to biological sciences, cell culture, genetics, molecular biology, or related disciplines. The project involves advanced 2D and 3D mammalian cell culture, CRISPR/Cas9-mediated genetic manipulation, and image-based high-throughput screening, so experience or interest in these areas is desirable. The opportunity is open to UK and international students and eligibility must meet UKRI/EASTBIO DTP criteria.

How to apply

Complete the EASTBIO Application Form and attach your academic transcripts as a PDF. Email the application materials to [email protected]. Also ask your referees to submit references using the EASTBIO reference form template to the same email address by the deadline.

More information can be found here

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