Publisher
source

Amsterdam UMC

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PhD in Gene Therapy for Leukodystrophies at Amsterdam UMC Amsterdam UMC in Netherlands

Degree Level

PhD

Field of study

Biomedical Engineering

Funding

PhD position within the MSCA-DN POLARIS doctoral network; the candidate will be employed by Amsterdam UMC and participate in network-wide training and secondments. The post is a funded doctoral research position, but no stipend amount or tuition details are stated in the post.

Deadline

Oct 5, 2026

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Country

Netherlands

University

Amsterdam UMC

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Keywords

Biomedical Engineering
Biology
Gene Therapy
Preclinical Research
Neuropsychology
Medical Science
Genome Editing
Mouse Model

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About this position

Amsterdam UMC in the Netherlands is recruiting for an MSCA-DN PhD position in Gene Therapy for Leukodystrophies within the POLARIS doctoral network. The project is part of a European Marie Skłodowska-Curie Doctoral Network focused on accelerating therapy development for leukodystrophies, with training in an international and interdisciplinary environment.

The PhD project centers on preclinical gene therapy research for vanishing white matter disease (VWM) and metachromatic leukodystrophy (MLD). The work includes testing the efficacy and safety of AAV gene therapy in mouse models, applying genome-editing approaches such as bridgeRNA-guided recombinases, and using molecular techniques and in vivo models to study disease mechanisms and treatment responses.

Academic supervision and disease-specific expertise will be provided by Dr Niek van Til at the Amsterdam Leukodystrophy Center. The project is embedded at Amsterdam UMC, with the anticipated PhD defence at the Faculty of Medicine, Vrije Universiteit Amsterdam. Planned secondments include hands-on experience in gene therapy vector production and work with the Vereniging voor Innovatieve Geneesmiddelen (VIG) on access pathways for advanced therapy medicinal products (ATMPs).

Eligibility highlights include relevant experience in molecular techniques and a strong interest in the responsible and scientifically robust use of mouse models in translational research. The network also offers training and transferable-skills development through POLARIS.

The deadline shown on the post is 5 Oct 2026. Applications should be submitted through the AcademicTransfer vacancy page linked in the post.

Funding details

PhD position within the MSCA-DN POLARIS doctoral network; the candidate will be employed by Amsterdam UMC and participate in network-wide training and secondments. The post is a funded doctoral research position, but no stipend amount or tuition details are stated in the post.

What's required

Relevant experience in molecular techniques is required, along with an interest in responsible and scientifically robust use of mouse models in translational research. The project is for a doctoral candidate and involves preclinical research, in vivo mouse models, and collaboration in an international interdisciplinary network.

How to apply

Apply via the AcademicTransfer job page linked in the post. Review the full vacancy details there and submit the application through the portal before the deadline. Use the link provided for the official application instructions.

More information can be found here

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