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University of Mainz

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PhD in Small Molecule Inhibitor Discovery and Structural Biology at University of Mainz University of Mainz in Germany

Degree Level

PhD

Field of study

Computer Science

Funding

3-year PhD position funded at TV-L E13 (65%) plus full social benefits.

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Country

Germany

University

University of Mainz

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Keywords

Computer Science
Chemistry
Biomedical Engineering
Biophysics
Biology
Structural Biology
X-ray Diffraction
Pharmacy
Nmr Spectroscopy
ML

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About this position

PhD opportunity at the University of Mainz, Germany, in the Czodrowski Lab on identification of new small molecule inhibitors for the aspartic protease endothiapepsin.

The project combines structural biology, machine learning, and biophysical methods such as ITC, STD NMR, X-ray diffraction, switchSENSE, and FRET to study drug discovery and protein-ligand interactions. The research aims to virtually identify and experimentally verify novel inhibitors structurally related to endothiapepsin, with a focus on proton transfer during protein-ligand complex formation.

Applicants should have a solid background in structural biology and biophysical methods, fluent English, and ideally German. The post also values dedication to teaching and mentoring undergraduates.

This is a 3-year PhD position funded at TV-L E13 (65%) with full social benefits. Preferred start is January 2027.

To apply, send a single PDF to [email protected] with subject line "PhD ET". Include a motivation letter, CV, a 2-page Master's thesis summary with graphical TOC, BSc/MSc transcripts, and 2 references.

Funding details

3-year PhD position funded at TV-L E13 (65%) plus full social benefits.

What's required

Solid background in structural biology and biophysical methods; fluent English; German is a strong bonus; dedication to teaching and mentoring undergraduates. Applicants should submit a single PDF including a motivation letter, CV, 2-page Master's thesis summary with graphical table of contents, BSc/MSc transcripts, and 2 references.

How to apply

Email a single PDF application to [email protected] with subject line "PhD ET". Include a motivation letter, CV, 2-page Master's thesis summary with graphical TOC, transcripts, and two references.

More information can be found here

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