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University of Mainz

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PhD Researcher Position in Structural Biology and Drug Discovery for Endothiapepsin Inhibitors University of Mainz in Germany

Degree Level

PhD

Field of study

Computer Science

Funding

3-year PhD position funded at TV-L E13, 65% with full social benefits. The post offers state-of-the-art facilities, labs, and professional development within an interdisciplinary network.

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Country

Germany

University

University of Mainz

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Keywords

Computer Science
Chemistry
Biophysics
Biology
Structural Biology
Chemical Biology
Medical Science
Physics
ML

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About this position

PhD Researcher position at the Czodrowski Lab, University of Mainz, Germany, in structural biology, drug discovery, chemical biology, and biophysical methods.

The project focuses on identifying new small molecule inhibitors for the aspartic protease endothiapepsin. The lab combines structural biology, machine learning, and experimental biophysics to study protein-ligand interactions and support discovery for unmet medical needs. Methods mentioned include ITC, STD NMR, X-ray diffraction, switchSENSE, FRET, and AI-driven approaches.

The post is a PhD opening with a preferred start in January 2027. It is a 3-year position funded at TV-L E13, 65% with full social benefits. The lab highlights state-of-the-art facilities, interdisciplinary collaborations, and broader professional growth.

Applicants should have a strong background in structural biology and biophysical methods, be highly motivated, and work autonomously with responsibility and initiative. English fluency is required; German is a strong bonus. Teaching and mentoring undergraduates is also valued.

To apply, send a single PDF to [email protected] with subject line “PhD ET”. Include a motivation letter focused on the proposed PhD project, CV, a 2-page summary of your Master’s thesis with graphical TOC, BSc/MSc transcripts, and contact details for two references.

Funding details

3-year PhD position funded at TV-L E13, 65% with full social benefits. The post offers state-of-the-art facilities, labs, and professional development within an interdisciplinary network.

What's required

Highly motivated candidate with a solid background in structural biology and biophysical methods. The post expects autonomy, responsibility, and initiative, plus fluency in English; German is a strong bonus. Dedication to teaching and mentoring undergraduates is also preferred. Applicants should have a Master's degree background suitable for a PhD project and provide transcripts, thesis summary, CV, motivation letter, and references.

How to apply

Send a single PDF by email to [email protected] with subject line 'PhD ET'. Include a motivation letter focused on the proposed PhD project, CV, a 2-page summary of your Master's thesis with graphical TOC, BSc/MSc transcripts, and contact details of two references. Referee letters are preferred if available.

More information can be found here

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