PhD Position: Finding the Missing Link between Aβ Exposure and Inhibitory Synaptic Defects Radboud University in Netherlands

This PhD position at Radboud University offers an exciting opportunity to investigate the molecular mechanisms underlying inhibitory synaptic defects in early Alzheimer's disease. The project is based in the Wierenga lab at the Donders Centre for Neuroscience, part of the Faculty of Science, and focuses on the vulnerability of inhibitory circuits to Aβ oligomers, a hallmark of Alzheimer's disease progression. The research aims to bridge the gap in understanding how rising levels of Aβ lead to synaptic dysfunction and network hyperexcitability, which are critical factors in cognitive decline.

As a PhD candidate, you will employ advanced techniques including single-cell electrophysiology, two-photon microscopy, and novel biosensors such as iGABASnFR2 to monitor GABA release and characterize synaptic defects in cultured brain slices from transgenic mice. The project also involves assessing molecular and electrophysiological changes to elucidate the involvement of specific signalling pathways. The research environment is highly collaborative, multidisciplinary, and international, with English as the working language.

The Donders Institute is renowned for its state-of-the-art facilities and stimulating research culture, housing over 800 researchers dedicated to understanding the brain at molecular, cellular, and systems levels. The Faculty of Science at Radboud University is committed to groundbreaking research and excellent education, fostering personal and professional development in an inclusive and diverse community.

Applicants should hold a Master's degree in life sciences, biology, biomedical sciences, neuroscience, or a related field, with a strong interest in intracellular signalling and optical recording methods. Experience in advanced microscopy, electrophysiology, and programming (Matlab or similar) is preferred, but candidates willing to learn are encouraged to apply. Fluency in English and strong communication skills are essential, along with the ability to work independently and as part of a team.

The position offers a temporary employment contract (1.0 FTE) for 1.5 years, with the possibility of extension to a total of 4 years based on performance. The starting salary is €3,059 gross per month, rising to €3,881 in the fourth year, plus an 8% holiday allowance and an 8.3% end-of-year bonus. Additional benefits include extra days off, flexible working hours, sports and cultural discounts, a pension plan, and access to training and development schemes.

Applications must be submitted online via the provided link, with a letter addressed to Prof. Corette Wierenga. The application form will specify required documents. The deadline for applications is 14 June 2026, and interviews are scheduled for the week of 22 June. The successful candidate will preferably start as soon as possible.

This position is ideal for motivated and enthusiastic young scientists eager to contribute to cutting-edge neuroscience research in a supportive and dynamic environment.