PhD Position: Finding the Missing Link Between Aβ Exposure and Inhibitory Synaptic Defects in Early Alzheimer's Disease Radboud University in Netherlands

This PhD position at Radboud University offers an exciting opportunity to investigate the molecular mechanisms underlying synaptic defects in early Alzheimer's disease (AD). The project is based in the Wierenga lab at the Donders Centre for Neuroscience, part of the Faculty of Science, and focuses on the vulnerability of inhibitory synapses to amyloid β (Aβ) oligomers. The research aims to elucidate how rising levels of Aβ in the brain contribute to synaptic dysfunction and network hyperexcitability, which are key factors in the progression of AD before cognitive symptoms appear.

As a PhD candidate, you will employ a combination of single-cell electrophysiology, advanced microscopy, and novel biosensors to characterize synaptic defects at inhibitory synapses in cultured brain slices exposed to Aβ oligomers. The project utilizes innovative iGABASnFR2 sensors in slices from transgenic mice to monitor Aβ-mediated changes in GABA release at specific inhibitory synapse subtypes. Parallel molecular and electrophysiological analyses will help assess the involvement of specific signaling pathways. The teaching load may be up to 10% of your working time.

The Wierenga lab is part of the world-renowned Donders Institute for Brain, Cognition and Behaviour, which houses over 800 researchers and offers state-of-the-art facilities for neuroscience research. The institute fosters a collaborative, multidisciplinary, and supportive environment with English as the working language. The Faculty of Science is highly international, with staff from over 70 countries, and provides excellent opportunities for personal and professional development.

Applicants should have a Master's degree in life sciences, biology, biomedical sciences, neuroscience, or a related discipline, with interest in intracellular signaling and optical recording methods. Experience in advanced microscopy, electrophysiology, and programming (Matlab or similar) is preferred, but willingness to learn is also valued. Candidates should be highly motivated, enthusiastic, critical, creative, and team-oriented, able to work independently and within a group, fluent in English, and possess strong communication skills, integrity, and positivity.

The position offers a temporary employment contract (1.0 FTE) for 1.5 years, extendable to 4 years upon positive evaluation. The starting salary is €3,059 gross per month, rising to €3,881 in the fourth year, with an 8% holiday allowance, 8.3% end-of-year bonus, extra days off (30 or 41 annual leave days), flexible working hours, pension plan, and discounts on sports and cultural activities. Radboud University is committed to excellent employment practices and work-life balance.

To apply, submit your application via the provided link, addressing your letter to Prof. Corette Wierenga. The application form will specify required documents. Interviews are scheduled for the week of 22 June 2026, and the preferred start date is as soon as possible. The application deadline is 14 June 2026.