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Institute of Biophysics, Czech Academy of Sciences

PhD Position in Genome Duplication, DNA Replication, and Genome Stability in Development and Disease Institute of Biophysics of the Czech Academy of Sciences in Czech Republic

Degree Level

PhD

Field of study

Cell Biology

Funding

Full funding available

Deadline

Sep 15, 2026

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Country

Czech Republic

University

Institute of Biophysics, Czech Academy of Sciences

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Keywords

Cell Biology
Biomedical Engineering
Biology
Stem Cell Biology
Microscopy
Developmental Biology
Genome Stability
Dna Replication
Genome Engineering
Genomic

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About this position

PhD position at the Institute of Biophysics of the Czech Academy of Sciences in Brno, Czech Republic, in the DNA Replication & Genome Stability Laboratory led by Dr. Hana Polasek-Sedlackova.

The project, How Cells Scale Genome Duplication During Development and Disease, focuses on fundamental questions in biology, cell biology, developmental biology, genome stability, and DNA replication. The lab studies how mammalian cells dynamically regulate DNA replication initiation across developmental and physiological contexts while preserving genome integrity and understanding how disruption contributes to disease, including cancer.

The successful candidate will join an international English-speaking research environment and will also be enrolled in the PhD programme Animal physiology, immunology and developmental biology at the Faculty of Science, Masaryk University.

Training includes CRISPR-based genome engineering, quantitative high-content imaging, live-cell microscopy, AI-assisted image analysis, stem cell biology and differentiation models, functional genomics, and proteomics.

This is a fully funded four-year PhD position with competitive salary and employee benefits, including social security, paid vacation, meal allowance, sports and recreation contributions, and on-site childcare. The lab also offers conference support, advanced training, international research stays, and relocation/administrative support for international applicants, including housing and visa assistance.

Applicants should hold a Master’s degree or equivalent in Molecular Biology, Cell Biology, Biochemistry, Biomedicine, or a related life science field, and have practical laboratory experience in molecular and/or cell biology, strong analytical and problem-solving skills, teamwork and communication skills, and good English proficiency. Experience with microscopy, genome editing, stem cell biology, computational image analysis, genomics, or proteomics is helpful but not required.

Application deadline: 15 September 2026. Submit a single PDF with a cover letter, CV, transcripts and degree certificates (or expected graduation confirmation), and contact details for at least two academic referees to [email protected] and [email protected].

Funding details

Full funding including tuition fees and living expenses is available for this position. The scholarship covers all educational costs and provides a monthly stipend.

How to apply

Please submit your application including a cover letter, CV, academic transcripts, and contact information for two references. Applications should be sent via the online portal before the deadline.

More information can be found here

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