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Institute of Biophysics, Czech Academy of Sciences

PhD Position in Genome Duplication, DNA Replication, and Genome Stability in Development and Disease Institute of Biophysics of the Czech Academy of Sciences in Czech Republic

Degree Level

PhD

Field of study

Cell Biology

Funding

Fully funded four-year PhD position with competitive salary, social security, employee benefits, five weeks of paid vacation, meal allowance, sports and recreation contributions, and on-site childcare. Support is also offered for conference participation, advanced training, international research stays, relocation, housing, and visa procedures.

Deadline

Sep 15, 2026

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Country

Czech Republic

University

Institute of Biophysics, Czech Academy of Sciences

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Keywords

Cell Biology
Biomedical Engineering
Biology
Stem Cell Biology
Microscopy
Developmental Biology
Genome Stability
Dna Replication
Genome Engineering
Genomic

About this position

PhD position at the Institute of Biophysics of the Czech Academy of Sciences in Brno, Czech Republic, in the DNA Replication & Genome Stability Laboratory led by Dr. Hana Polasek-Sedlackova.

The project, How Cells Scale Genome Duplication During Development and Disease, focuses on fundamental questions in biology, cell biology, developmental biology, genome stability, and DNA replication. The lab studies how mammalian cells dynamically regulate DNA replication initiation across developmental and physiological contexts while preserving genome integrity and understanding how disruption contributes to disease, including cancer.

The successful candidate will join an international English-speaking research environment and will also be enrolled in the PhD programme Animal physiology, immunology and developmental biology at the Faculty of Science, Masaryk University.

Training includes CRISPR-based genome engineering, quantitative high-content imaging, live-cell microscopy, AI-assisted image analysis, stem cell biology and differentiation models, functional genomics, and proteomics.

This is a fully funded four-year PhD position with competitive salary and employee benefits, including social security, paid vacation, meal allowance, sports and recreation contributions, and on-site childcare. The lab also offers conference support, advanced training, international research stays, and relocation/administrative support for international applicants, including housing and visa assistance.

Applicants should hold a Master’s degree or equivalent in Molecular Biology, Cell Biology, Biochemistry, Biomedicine, or a related life science field, and have practical laboratory experience in molecular and/or cell biology, strong analytical and problem-solving skills, teamwork and communication skills, and good English proficiency. Experience with microscopy, genome editing, stem cell biology, computational image analysis, genomics, or proteomics is helpful but not required.

Application deadline: 15 September 2026. Submit a single PDF with a cover letter, CV, transcripts and degree certificates (or expected graduation confirmation), and contact details for at least two academic referees to [email protected] and [email protected].

Funding details

Fully funded four-year PhD position with competitive salary, social security, employee benefits, five weeks of paid vacation, meal allowance, sports and recreation contributions, and on-site childcare. Support is also offered for conference participation, advanced training, international research stays, relocation, housing, and visa procedures.

What's required

Applicants should have a Master’s degree or equivalent in Molecular Biology, Cell Biology, Biochemistry, Biomedicine, or a related life science discipline. Required experience includes practical laboratory work in molecular and/or cell biology, strong analytical thinking and problem-solving skills, excellent communication and teamwork skills, and proficiency in spoken and written English. Previous experience with microscopy, genome editing, stem cell biology, computational image analysis, genomics, or proteomics is advantageous but not required.

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