Amsterdam UMC
6 days ago
PhD Position in Molecular Pharmacology and GPCR Drug Discovery Amsterdam UMC in Netherlands
Degree Level
PhD
Field of study
Chemistry
Funding
MSCA Doctoral Network PhD position; funding is implied through the Marie Skłodowska-Curie Doctoral Network, with training, secondments, and network-wide development. No stipend amount, tuition coverage, or other financial details are stated.
Deadline
Oct 5, 2026
Country
Netherlands
University
Amsterdam UMC

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About this position
MSCA-DN PhD position in Molecular Pharmacology at Amsterdam UMC / Vrije Universiteit Amsterdam in the Netherlands.
This doctoral project is part of the POLARIS doctoral network, a European Marie Skłodowska-Curie Doctoral Network focused on accelerating therapy development for leukodystrophies and related rare genetic brain disorders. The project centers on an orphan GPCR as a potential drug target for megalencephalic leukoencephalopathy with subcortical cysts (MLC).
You will work on molecular receptor pharmacology, GPCR signalling, assay development, high-throughput screening, FDA-approved drug repurposing, and fragment-based drug discovery. Planned work includes developing cell-based bioluminescent and fluorescent biosensor assays, investigating receptor activation and signalling, identifying drug-like modulators, and contributing to a functional GPCR assay pipeline. Promising compounds may later be evaluated in cellular and in vivo disease models.
The network offers an international and interdisciplinary training environment with secondments, hands-on assay validation, in vivo characterisation, and transferable-skills development. The post is especially relevant for candidates with interests in pharmacology, medicinal chemistry, chemical biology, neuroscience, and translational drug discovery.
Deadline: 5 October 2026.
Apply via: AcademicTransfer official vacancy page.
Funding details
MSCA Doctoral Network PhD position; funding is implied through the Marie Skłodowska-Curie Doctoral Network, with training, secondments, and network-wide development. No stipend amount, tuition coverage, or other financial details are stated.
What's required
Applicants should be interested in molecular receptor pharmacology, GPCR signalling, assay development, high-throughput screening, and drug discovery. The project involves cell-based bioluminescent and fluorescent biosensor assays, FDA-approved drug library repurposing, fragment-based drug discovery, and collaboration across an international doctoral network. No specific degree, GPA, or language-test requirements are stated in the post.
How to apply
Apply via the AcademicTransfer posting linked in the announcement. Review the full job ad for eligibility and application instructions, then submit through the application portal before the deadline. Use the provided link to access the official vacancy page.
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