Institut national de la santé et de la recherche médicale
1 week ago
PhD position in myotendinous junction local translation and RNA-binding proteins Institut national de la santé et de la recherche médicale in France
Degree Level
PhD
Field of study
Biochemistry
Funding
Available
Deadline
Oct 20, 2026
Country
France
University
Institut national de la santé et de la recherche médicale
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About this position
PhD position in biological sciences focused on the myotendinous junction (MTJ), a mechanically important region of skeletal muscle that is highly prone to injury during exercise.
The project is hosted by Inserm U1258 at IGBMC in Illkirch, France, and is linked to a Horizon Europe / ERC-funded research environment.
The lab has developed a new tool to manipulate the MTJ domain and has already identified a local translational program and exercise-induced rewiring. The successful candidate will investigate the molecular mechanisms that control this specialised translation program.
The work combines candidate-driven and unbiased approaches. Planned research includes generating mouse mutants for candidate RNA-binding proteins, analysing their phenotypes, studying the local translatome after mutation, identifying binding partners, and performing biochemical pull-down experiments using affinity-tagged UTRs.
The position is well suited to a student interested in skeletal muscle biology, RNA biology, translation control, and experimental mouse work. The project involves a mix of genetics, histology, imaging, physiological phenotyping, biochemistry, mass spectrometry, and NGS-based analyses.
Applicants should hold a Master degree or equivalent in biological sciences, with strong practical experience or willingness to develop expertise in mouse genetics, muscle phenotyping, and molecular/biochemical methods. Excellent English and good communication, independence, and teamwork are important.
The position is full-time and temporary, with one vacancy available. Deadline: 20 October 2026. Applications should be sent by email to [email protected].
Funding details
Available
What's required
Master degree or equivalent in biological sciences is required. The applicant should have mouse genetics skills including maintenance, genotyping, histological analyses, and imaging, as well as experience with physiological tests for muscle function phenotyping and biochemical skills relevant to mass spectrometry and NGS. Strong communication skills in presentation and writing, collaborative team spirit, independence, and excellent English are expected.
How to apply
Apply by email to [email protected] with a message for the PhD position. Use the provided contact email in the application materials or inquiry if needed.
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