Nina Khanna Gremmelmaier
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PhD Position in TCR Discovery and Cellular Immunotherapy University of Basel in Switzerland
Degree Level
PhD
Field of study
Immunology
Funding
Full funding availableDeadline
Sep 3, 2026
Country
Switzerland
University
University of Basel
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About this position
The University of Basel’s Department of Biomedicine is offering a fully funded PhD position in TCR Discovery and Cellular Immunotherapy within the Infection Biology laboratory led by Prof. Nina Khanna Gremmelmaier.
This project focuses on T-cell immunity in Epstein–Barr virus (EBV)-associated cancers and aims to identify novel tumor-reactive T-cell receptors (TCRs) for next-generation adoptive cellular therapies. The work is embedded in a translational research program with close links to clinicians, GMP manufacturing facilities, and clinical trial units, offering a rare opportunity to engage in both basic discovery and clinical implementation.
The successful candidate will work with patient-derived tumor models and advanced experimental platforms, including CRISPR/Cas9 genome engineering, immunopeptidomics, single-cell multiomics, and functional immunology. Key responsibilities include establishing EBV-positive tumor models, engineering HLA-defined target cells, isolating and characterizing tumor-infiltrating lymphocytes, profiling immune cell transcriptomes and TCR repertoires, reconstructing and validating candidate TCRs, and performing multicolor flow cytometry, T-cell expansion, cytokine, proliferation, and cytotoxicity assays.
The position is suited to a highly motivated MSc-level candidate in immunology, molecular biology, cell biology, biotechnology, biomedical sciences, or a related discipline. Strong laboratory experience, analytical thinking, good English, and a willingness to learn new experimental and computational methods are emphasized. Experience in cancer biology, viral or cellular immunology, CRISPR/Cas9 editing, single-cell sequencing, immunopeptidomics, or R/Python-based analysis would be advantageous.
Basel offers an internationally collaborative research environment across the University of Basel and University Hospitals Basel. The role includes training in cutting-edge technologies, close supervision, opportunities for international presentations and high-impact publications, and strong career mentoring.
Applications should include a CV, motivation letter, academic transcripts and degree certificates, and the contact details of two or three referees. The position is available immediately or by agreement, with a preferred start in November 2026, and remains open until filled. Application deadline: 2026-09-03.
Funding details
Full funding including tuition fees and living expenses is available for this position. The scholarship covers all educational costs and provides a monthly stipend.
How to apply
Please submit your application including a cover letter, CV, academic transcripts, and contact information for two references. Applications should be sent via the online portal before the deadline.
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